evaluation of two monkey species (macaca mulatta and macaca fascicularis) as possible models for human helicobacter pylori disease.endoscopic, histologic, and microbiologic evaluations of 21 cynomolgus and 34 rhesus monkeys for naturally occurring helicobacter pylori infection were done. h. pylori was never isolated from any cynomolgus monkey, but was found in 12 rhesus monkeys. a general correlation existed between a positive culture and a gastric inflammatory response. inoculation challenges were then undertaken. four cynomolgus and five rhesus monkeys received two different h. pylori strains isolated from humans. five rh ...19902229353
adhesion of helicobacter pylori to gastric epithelial cells in primary cultures obtained from stomachs of various animals.of 35 strains of helicobacter pylori tested, 5 were found to adhere well to hep-2 cells. we selected three of these adhesive strains and four from the remaining strains to examine their ability to adhere to gastric epithelial cells in primary cultures obtained by collagenase digestion of stomachs from mice, rats, mongolian gerbils, guinea pigs, pigs, and cynomolgus monkeys. the three adhesive strains adhered well to epithelial cells from monkey and pig gastric antra. the adhesion was inhibited b ...19937691743
serial change of gastric mucosa after challenging with helicobacter pylori in the cynomolgus monkey.the aim of this study was to clarify the change of the gastric mucosa following inoculation with helicobacter pylori (h. pylori). two pairs of cynomolgus monkeys received either h. pylori of human origin (group a) or h. pylori of monkey origin (group b) by intragastric inoculation at a dose of 10(9) cfu. after inoculation, endoscopical observation and biopsies were done every 7 days for one month. the bacteria in the biopsy samples were cultured quantitatively. the content of intracellular pas-a ...19938280957
[experimental infection of the cynomolgus monkey with helicobacter pylori].to better understand the pathogenesis of helicobacter pylori (h. pylori) associated gastritis and to evaluate the effectiveness of potential therapies in ulcer healing, we established an experimental animal model of h. pylori infection. a strain of h. pylori was isolated from the stomach of a cynomolgus monkey, cultured and used to inoculate as a group of h. pylori negative monkeys. h. pylori-induced changes in the gastric mucosa was monitored both endoscopically and by histological evaluation o ...19938283619
[helicobacter pylori and urease activity--comparative study between urease positive and negative mutant strains].the ammonia concentration in the gastric juice from h. pylori positive cases was significantly higher than that from negative cases, and there was positive correlation between number of h. pylori, gastritis score and ammonia concentration in gastric juice. it is suggested that ammonia in gastric juice which is produced by powerful urease activity of h. pylori is one of the pathogenic factors in gastritis. we succeeded in producing a urease-negative mutant strain of h. pylori. this strain did not ...19938283623
an epizootic of lymphoplasmacytic gastritis attributed to helicobacter pylori infection in cynomolgus monkeys (macaca fascicularis).an epizootic of subclinical lymphoplasmacytic gastritis occurred in cynomolgus monkeys maintained at our research facility. gastric pathology data and histologic sections of 63 adolescent monkeys (2.5-3.5 years old) sacrificed during the epizootic were reviewed. localized to multifocal reddening of the gastric mucosa was noted grossly in 7 of 44 (16%) monkeys harboring helicobacter pylori, but not in any of 19 monkeys in which these bacteria were not seen. gastritis, characterized by accentuatio ...19999921750
molecular characterization of helicobacter pylori strains isolated from cynomolgus monkeys (m. fascicularis).we recently reported the occurrence of natural infection with h. pylori in a group of cynomolgus monkeys with chronic active gastritis and gastric erosions. the goal of the present study was to characterize and to compare strains isolated from animals originating from two different geographical areas. gross and microscopic pathology determined at the time of necropsy was similar in all animals. h. pylori were isolated from specimens harvested in five monkeys (four from vietnam and one from the p ...200515885930
a review of background findings in cynomolgus monkeys (macaca fascicularis) from three different geographical origins.this review was performed to assess variations in background observations in cynomolgus macaques (macaca fascicularis) originating from three breeding centres located in mauritius, the philippines and vietnam. the data and tissue samples from 90 cynomolgus monkeys (approximately evenly distributed between the three sources) comprising the control groups from 11 regulatory toxicology studies were used for this investigation. clinical data--age, body weight, organ weights, haematology and serum bi ...200616984807
"candidatus helicobacter heilmannii" from a cynomolgus monkey induces gastric mucosa-associated lymphoid tissue lymphomas in c57bl/6 mice.both helicobacter pylori and "candidatus helicobacter heilmannii" infections are associated with peptic ulcers, gastric adenocarcinoma, and gastric mucosa-associated lymphoid tissue (malt) lymphomas. however, good animal models of h. pylori clinical diseases are rare. in this study, we aimed to establish an animal model of "candidatus helicobacter heilmannii" gastric malt lymphoma. we used a urease-positive gastric mucosal and mucus homogenate from a cynomolgus monkey maintained in c57bl/6 mouse ...200717194807
histopathology of incidental findings in cynomolgus monkeys ( macaca fascicularis ) used in toxicity studies.the purpose of our publication is to widely communicate pictures of spontaneous findings occurring in cynomolgus monkeys. focal lymphoplasmacytic infiltration is commonly seen in the general organs. the frequency and severity of these lesions may be influenced by the administration of drugs with an effect on the immune system. lymphoplasmacytic infiltration in the lamina propria of the stomach is also frequently seen in cynomolgus monkeys, and it is caused mainly by a helicobacter pylori infecti ...201222481861
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