| animal pharmacokinetics and interspecies scaling of sordarin derivatives following intravenous administration. | sordarin derivatives constitute a new group of synthetic antifungal agents that selectively inhibit fungal protein synthesis. they have demonstrated in vitro activity against the most important fungal pathogens, both yeast and filamentous. this new family of compounds has also shown in vivo activity against murine candida albicans, histoplasma capsulatum, and coccidioides immitis experimental infections, as well as against pneumocystis carinii pneumonia in rats. after intravenous dosing in anima ... | 2001 | 11557470 |