| establishment and transcriptomic features of an immortalized hepatic cell line of the chinese tree shrew. | the chinese tree shrew (tupaia belangeri chinesis) is a rising experimental animal and has been used for studying a variety of human diseases, such as metabolic and viral infectious diseases. | 2020 | 32880691 |
| tupaia mavs is a dual target during hepatitis c virus infection for innate immune evasion and viral replication via nf-κb. | hepatitis c virus (hcv) infection is the cause of severe liver disease in many people. the restricted species tropism of hcv hinders the research and development of drugs and vaccines. the chinese tree shrew (tupaia belangeri chinensis) is a close relative of primates and can be infected by hcv, but the underlying mechanisms are unknown. in this study, we have characterized the functions of tree shrew mavs (tmavs) in response to hcv infection and defined the capacity of hcv replication. hcv was ... | 2020 | 32907995 |
| creating animal models, why not use the chinese tree shrew (tupaia belangeri chinensis)? | the chinese tree shrew (tupaia belangeri chinensis), a squirrel-like and rat-sized mammal, has a wide distribution in southeast asia, south and southwest china and has many unique characteristics that make it suitable for use as an experimental animal. there have been many studies using the tree shrew (tupaia belangeri) aimed at increasing our understanding of fundamental biological mechanisms and for the modeling of human diseases and therapeutic responses. the recent release of a publicly avai ... | 2017 | 28585435 |
| tree shrew, a potential animal model for hepatitis c, supports the infection and replication of hcv in vitro and in vivo. | the tree shrew (tupaia belangeri chinensis), a small animal widely distributed in southeast asia and southwest china, has the potential to be developed as an animal model for hepatitis c. to determine the susceptibility of the tree shrew to hepatitis c virus (hcv) infection in vitro and in vivo, a well-established hcv, produced from the j6/jfh1-huh7.5.1 culture system, was used to infect cultured primary tupaia hepatocytes (pths) and tree shrews. the in vitro results showed that hcv genomic rna ... | 2017 | 28758632 |
| identification and characterization of liver micrornas of the chinese tree shrew via deep sequencing. | chinese tree shrew (tupaia belangeri chinensis) is a small animal that possess many features, which are valuable in biomedical research, as experimental models. currently, there are numerous attempts to utilize tree shrews as models for hepatitis c virus (hcv) infection. | 2015 | 26587035 |
| identification and characterization of toll-like receptors (tlrs) in the chinese tree shrew (tupaia belangeri chinensis). | in mammals, the toll-like receptors (tlrs) play a major role in initiating innate immune responses against pathogens. comparison of the tlrs in different mammals may help in understanding the tlr-mediated responses and developing of animal models and efficient therapeutic measures for infectious diseases. the chinese tree shrew (tupaia belangeri chinensis), a small mammal with a close relationship to primates, is a viable experimental animal for studying viral and bacterial infections. in this s ... | 2016 | 26923770 |
| metabolomic analysis of key regulatory metabolites in hepatitis c virus-infected tree shrews. | metabolomics is a powerful new technology that allows the assessment of global low-molecular-weight metabolites in a biological system and which shows great potential in biomarker discovery. analysis of the key metabolites in body fluids has become an important part of improving the diagnosis, prognosis, and therapy of diseases. hepatitis c virus (hcv) is a major leading cause of liver disease worldwide and a serious burden on public health. however, the lack of a small-animal model has hampered ... | 2012 | 23264353 |
| transmission of hepatitis c virus infection to tree shrews. | although hepatitis c virus (hcv) infection can be reproduced in chimpanzees, these animals are rare and expensive. tree shrews (tupaias) are small animals, closely related to primates, which adapt easily to a laboratory environment. in this work we have investigated the susceptibility of tupaia belangeri chinensis to hcv infection. tupaias caught in the wild in yunnan (china) were inoculated in china with hcv genotype 1b (study a) and in spain with a mixture of genotypes 1b, 1a, and 3 (study b). ... | 1998 | 9601519 |