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synergistic effect of hepatitis b virus and aflatoxin b1 in hepatocarcinogenesis in tree shrews.an animal experiment with tree shrews was performed to detect the synergistic effects of hepatitis b virus (hbv) infection and dietary aflatoxin b1 (afb1) in hepatocarcinogenesis. adult healthy tree shrews (tupaia belangeri chinensis) were divided into four groups: group a (hbv + afb1)--animals were infected with human hbv serum at first, then fed afb1 diluted with milk, 150 ug/kg.bw/day, 6 days/week for 105 weeks. group b (hbv)--animals were infected with human hbv as group a, but no afb1 treat ...199910374028
[differentially expressed genes in hepatocellular carcinoma of tree shrew induced by different factors].previous studies on differentially expressed genes in hepatocellular carcinoma (hcc) used to perform with para-cancerous tissues as normal control. however, the para-cancerous tissue of hcc is actually abnormal because they frequently contain hepatitis, cirrhosis, hyperplastic nodules or foci, etc. in order to explore the molecular mechanism and the responsible genes for hepatocarcinogenesis, through applying the hcc model of tree shrew (tupaia belangeri chinensis), this study was designed to co ...200314558942
histopathological changes in the liver of tree shrew (tupaia belangeri chinensis) persistently infected with hepatitis b virus.an animal model for hbv that more closely approximates the disease in humans is needed. the tree shrew (tupaia belangeri) is closely related to primates and susceptible to hbv. we previously established that neonatal tree shrews can be persistently infected with hbv in vivo, and here present a six year follow-up histopathological study of these animals.201324220021
experimental chronic hepatitis b infection of neonatal tree shrews (tupaia belangeri chinensis): a model to study molecular causes for susceptibility and disease progression to chronic hepatitis in humans.hepatitis b virus (hbv) infection continues to be an escalating global health problem. feasible and effective animal models for hbv infection are the prerequisite for developing novel therapies for this disease. the tree shrew (tupaia) is a small animal species evolutionary closely related to humans, and thus is permissive to certain human viral pathogens. whether tree shrews could be chronically infected with hbv in vivo has been controversial for decades. most published research has been repor ...201222913805
[factors influencing long-term hepatitis b virus infection of the tree shrew (tupaia belangeri chinensis) as an in vivo model of chronic hepatitis b].to determine the methods for establishing an in vivo model of long-term hepatitis b virus (hbv) infection in the chinese tree shrew (tupaia belangeri chinensis).201223207228
chronic hepatitis b virus infection and occurrence of hepatocellular carcinoma in tree shrews (tupaia belangeri chinensis).hepatitis b virus (hbv) infection has been believed as a major cause of hepatocellular carcinoma (hcc) for a long time, however, the evidences of which are mostly from clinical and epidemiological investigations while there is no evidence from animal experiments. tree shrew (tupaia) is a small animal closely related to primates evolutionarily, with about 8 years of lifespan. our previous study proved that tree shrews can be chronically hbv-infected after being inoculated neonatally with hbv. the ...201525889678
[sero-epidemiology of six viruses natural infection in tupaia belangeri chinensis].tupaia (tupaia belangeris chinensis, tree shrew) as a new experiment animal in medicine are non-rodent, small animals and close to primates in evolution. experimental animals infected with viruses will affect the animal's health, interference experiment, and even endanger the operator's safety. therefore, the viral infection in experimental animals has long been considered an important part of quality control. lack of clearer viral natural infection information on the t. belangeris limits its us ...201121341379
mutations in the p53 tumor suppressor gene in tree shrew hepatocellular carcinoma associated with hepatitis b virus infection and intake of aflatoxin b1.infection with hepadnaviruses and exposure to aflatoxin b1 (afb1) are considered to be major risk factors in the development of hepatocellular carcinoma (hcc) in humans. a high rate of p53 mutations at codon 249 has been reported in these tumors. the tree shrew (tupaia belangeri chinensis) is a useful animal model for the development of hcc after human hepatitis b virus (hbv) infection or afb1 treatment. therefore, it was of particular interest to determine whether the p53 gene in tree shrew hcc ...200010863098
reduction of aflatoxin b(1) adduct biomarkers by oltipraz in the tree shrew (tupaia belangeri chinensis).the risk of liver cancer is greatest in people both infected with hepatitis b virus (hbv) and highly exposed to aflatoxin b(1) (afb(1)). the tree shrew (tupaia belangeri chinensis) is a unique species that can be infected with human hbv, is susceptible to afb(1)-induced liver cancer, and shows a synergistic interaction between hbv and afb(1) for liver cancer. in this regard, the tree shrew may be useful for evaluating experimental chemoprevention strategies relevant to high-risk human population ...200010799742
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