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viral vector vaccines expressing nucleoprotein and phosphoprotein genes of avian bornaviruses ameliorate homologous challenge infections in cockatiels and common canaries.avian bornaviruses are causative agents of proventricular dilatation disease (pdd), an often fatal disease of parrots and related species (order psittaciformes) which is widely distributed in captive psittacine populations and may affect endangered species. here, we established a vaccination strategy employing two different well described viral vectors, namely recombinant newcastle disease virus (ndv) and modified vaccinia virus ankara (mva) that were engineered to express the phosphoprotein and ...201627830736
viral vector vaccines protect cockatiels from inflammatory lesions after heterologous parrot bornavirus 2 challenge infection.avian bornaviruses are causative agents of proventricular dilatation disease (pdd), a chronic neurologic and often fatal disorder of psittacines including endangered species. to date no causative therapy or immunoprophylaxis is available. our previous work has shown that viral vector vaccines can delay the course of homologous bornavirus challenge infections but failed to protect against pdd when persistent infection was not prevented. the goal of this study was to refine our avian bornavirus va ...201728017426
recombinant modified vaccinia virus ankara (mva) vaccines efficiently protect cockatiels against parrot bornavirus infection and proventricular dilatation disease.parrot bornaviruses (pabvs) are the causative agents of proventricular dilatation disease (pdd), a chronic and often fatal neurologic disorder in psittaciformes. the disease is widely distributed in private parrot collections and threatens breeding populations of endangered species. thus, immunoprophylaxis strategies are urgently needed. in previous studies we demonstrated a prime-boost vaccination regime using modified vaccinia virus ankara (mva) and newcastle disease virus (ndv) constructs exp ...201931817690
wounds as the portal of entrance for parrot bornavirus 4 (pabv-4) and retrograde axonal transport in experimentally infected cockatiels (nymphicus hollandicus).in this study, we investigated the natural route of infection of psittacine bornavirus (pabv), which is the causative agent of proventricular dilatation disease (pdd) in psittacines. we inoculated two infection groups through wounds with a pabv-4 isolate. in nine cockatiels (nymphicus hollandicus) we applied a virus suspension with a titer of 103 50% tissue culture infection dose (tcid50) via palatal lesions (group p, p1-9). in a second group of three cockatiels, we applied a virus suspension wi ...202033205181
age-dependent development and clinical characteristics of an experimental parrot bornavirus-4 (pabv-4) infection in cockatiels (nymphicus hollandicus).parrot bornavirus (pabv) is a pathogen often found in psittacine populations. infected, clinically healthy carrier birds are of major importance for epidemiology, but the underlying pathomechanism of this carrier status is poorly understood. the age, implying the maturation status of the immune system, at the time of infection might be significant for the clinical outcome. therefore, two groups of 11 cockatiels of different ages (adult and newly hatched) were inoculated with a pabv-4 isolate int ...202133215512
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