Publications

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the continuous cultivation of plasmodium fragile by the method of trager-jensen.using the trager-jensen method, a second malaria species, plasmodium fragile, a simian counterpart to the human malaria p. falciparum, has been cultivated successfully. the average growth rate every 3--4 days was 5-fold and the average number of merozoites observed was 14. to date, only rhesus monkey red blood cells (rbc) would support the long-term cultivation of this parasite. short-term observations indicate that rbc from the squirrel monkey (saimiri sciureus) may support growth but human rbc ...1979110165
transmission of plasmodium fragile to saimiri monkeys.saimiri monkeys from bolivia and guyana were infected with the nilgiri and ceylon strains of plasmodium fragile. of 20 attempted sporozoite transmissions of the ceylon strain involving 11 splenectomized saimiri sciureus boliviensis, only 8 were successful, 2 by mosquito bite and 6 by intravenous injection of sporozoites dissected from salivary glands. prepatent periods ranged from 18 to 30 days with a mean of 25.8 days.19902213417
protective immunity induced in squirrel monkeys with recombinant apical membrane antigen-1 of plasmodium fragile.saimiri sciureus boliviensis monkeys were immunized with the plasmodium fragile form of the merozoite apical membrane antigen-1 produced using the baculovirus expression system and combined with montanide isa 720 adjuvant. following three immunizations, monkeys were challenged with 10,000 p. fragile trophozoite parasites. antibody titers determined by fluorescence microscopy indicated an enhanced response following the second immunization. four of five control animals had parasite counts > 5% 18 ...19947810803
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