Publications

inoculation of baboons and macaques with simian immunodeficiency virus/mne, a primate lentivirus closely related to human immunodeficiency virus type 2.	a primate lymphotropic lentivirus was isolated on the human t-cell line hut 78 after cocultivation of a lymph node from a pig-tailed macaque (macaca nemestrina) that had died with malignant lymphoma. this isolate, originally designated m. nemestrina immunodeficiency virus (mniv) and now classified as simian immunodeficiency virus (siv/mne), was inoculated intravenously into three juvenile rhesus monkeys (macaca mulatta), three juvenile pig-tailed macaques (m. nemestrina), and two juvenile baboon ...	1988	3285032
prevalence of antibodies to siv in baboons in their native habitat.	we have documented rare infection of baboons in their native habitat with simian immunodeficiency virus (siv). of 124 sera collected from yellow baboons in central tanzania, two gave high readings by sivagm elisa (greater than 1.0) and moderate by sivmac elisa (0.5-1.0). these two sera gave strong reactions to the major sivagm proteins, including gp130, by western blot analysis; their reactivity to sivmac protein was considerably weaker. similar testing of 155 sera from olive baboons of ethiopia ...	1989	2543434
mosaic genome structure of simian immunodeficiency virus from west african green monkeys.	elucidation of the phylogenetic origins of simian and human immunodeficiency viruses (siv and hiv) is fundamental to the understanding of hiv pathogenesis and the spread of aids worldwide. in this study, we molecularly characterized multiple sivagm isolates from four different african green monkey species (vervet, grivet, sabaeus and tantalus monkeys). phylogenetic analysis of partial (1 kb) env sequences indicated that all sivagm strains cluster together, and that they fall into four distinct s ...	1994	8026477
infection of a yellow baboon with simian immunodeficiency virus from african green monkeys: evidence for cross-species transmission in the wild.	many african primates are known to be naturally infected with simian immunodeficiency viruses (sivs), but only a fraction of these viruses has been molecularly characterized. one primate species for which only serological evidence of siv infection has been reported is the yellow baboon (papio hamadryas cynocephalus). two wild-living baboons with strong sivagm seroreactivity were previously identified in a tanzanian national park where baboons and african green monkeys shared the same habitat (t. ...	1994	7966642
simian immunodeficiency virus from mandrill (mandrillus sphinx) sivmnd experimentally infects human and nonhuman primate cells.	this study set out to characterize the features of experimental infection by simian immunodeficiency virus in mandrill (sivmnd) (mandrillus sphinx), cynomolgus macaque (macaca fascicularis), rhesus macaque (macaca mulatta), chimpanzee (pan troglodytes), african green monkey (cercopithecus pygerythrus), baboon (papio cynocephalus) and human cells. purified cells were exposed to a primary isolate of sivmnd grown in the infected mandrill peripheral blood mononuclear cells, and viral p27 gag antigen ...	2001	11445446
serological detection of adenoviruses in non-human primates maintained in a colony in kenya.	adenoviruses are known to cause several human diseases including acute febrile respiratory syndromes, epidemic conjunctivitis and gastroenteritis. these diseases associated with adenovirus infection affect adults and are usually more severe in infants and children. forty-seven human adenoviruses serotypes have so far been identified adenovirus. the diversity of these viruses has delayed progress on vaccine development due to difficulties in identifying appropriate vaccine targets. to date, limit ...	2005	16167712
host and viral traits predict zoonotic spillover from mammals.	the majority of human emerging infectious diseases are zoonotic, with viruses that originate in wild mammals of particular concern (for example, hiv, ebola and sars). understanding patterns of viral diversity in wildlife and determinants of successful cross-species transmission, or spillover, are therefore key goals for pandemic surveillance programs. however, few analytical tools exist to identify which host species are likely to harbour the next human virus, or which viruses can cross species ...	2017	28636590
global mammal parasite database version 2.0.	illuminating the ecological and evolutionary dynamics of parasites is one of the most pressing issues facing modern science, and is critical for basic science, the global economy, and human health. extremely important to this effort are data on the disease-causing organisms of wild animal hosts (including viruses, bacteria, protozoa, helminths, arthropods, and fungi). here we present an updated version of the global mammal parasite database, a database of the parasites of wild ungulates (artioda ...	2017	28273333
variable baseline papio cynocephalus endogenous retrovirus (pcev) expression is upregulated in acutely siv-infected macaques and correlated to stat1 expression in the spleen.	retroviral replication leaves a dna copy in the host cell chromosome, which over millions of years of infection of germline cells has led to 5% of the human genome sequence being comprised of endogenous retroviruses (ervs), distributed throughout an estimated 100,000 loci. over time these loci have accrued mutations such as premature stop codons that prevent continued replication. however, many loci remain both transcriptionally and translationally active and ervs have been implicated in interac ...	2019	31156613