Publications

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detection of simian t-lymphotropic virus type i using the polymerase chain reaction.to develop the polymerase chain reaction (pcr) for the detection of simian t-lymphotropic virus type i (stlv-i) infection, cell lines or peripheral-blood mononuclear cells (pbmc) from 2 non-human primate species [african green monkeys (agm), cercopithecus aethiops; baboon, papio cynocephalus] were evaluated for their stlv-i status using oligonucleotide primer pairs and probes specific for the tax and pol gene regions of the closely related human t-lymphotropic virus type i (htlv-i). these pcr re ...19921312066
prevalence of antibodies to siv in baboons in their native habitat.we have documented rare infection of baboons in their native habitat with simian immunodeficiency virus (siv). of 124 sera collected from yellow baboons in central tanzania, two gave high readings by sivagm elisa (greater than 1.0) and moderate by sivmac elisa (0.5-1.0). these two sera gave strong reactions to the major sivagm proteins, including gp130, by western blot analysis; their reactivity to sivmac protein was considerably weaker. similar testing of 155 sera from olive baboons of ethiopia ...19892543434
inoculation of baboons and macaques with simian immunodeficiency virus/mne, a primate lentivirus closely related to human immunodeficiency virus type 2.a primate lymphotropic lentivirus was isolated on the human t-cell line hut 78 after cocultivation of a lymph node from a pig-tailed macaque (macaca nemestrina) that had died with malignant lymphoma. this isolate, originally designated m. nemestrina immunodeficiency virus (mniv) and now classified as simian immunodeficiency virus (siv/mne), was inoculated intravenously into three juvenile rhesus monkeys (macaca mulatta), three juvenile pig-tailed macaques (m. nemestrina), and two juvenile baboon ...19883285032
infection of a yellow baboon with simian immunodeficiency virus from african green monkeys: evidence for cross-species transmission in the wild.many african primates are known to be naturally infected with simian immunodeficiency viruses (sivs), but only a fraction of these viruses has been molecularly characterized. one primate species for which only serological evidence of siv infection has been reported is the yellow baboon (papio hamadryas cynocephalus). two wild-living baboons with strong sivagm seroreactivity were previously identified in a tanzanian national park where baboons and african green monkeys shared the same habitat (t. ...19947966642
simian immunodeficiency virus from mandrill (mandrillus sphinx) sivmnd experimentally infects human and nonhuman primate cells.this study set out to characterize the features of experimental infection by simian immunodeficiency virus in mandrill (sivmnd) (mandrillus sphinx), cynomolgus macaque (macaca fascicularis), rhesus macaque (macaca mulatta), chimpanzee (pan troglodytes), african green monkey (cercopithecus pygerythrus), baboon (papio cynocephalus) and human cells. purified cells were exposed to a primary isolate of sivmnd grown in the infected mandrill peripheral blood mononuclear cells, and viral p27 gag antigen ...200111445446
serological detection of adenoviruses in non-human primates maintained in a colony in kenya.adenoviruses are known to cause several human diseases including acute febrile respiratory syndromes, epidemic conjunctivitis and gastroenteritis. these diseases associated with adenovirus infection affect adults and are usually more severe in infants and children. forty-seven human adenoviruses serotypes have so far been identified adenovirus. the diversity of these viruses has delayed progress on vaccine development due to difficulties in identifying appropriate vaccine targets. to date, limit ...200516167712
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