| mucosal immunization with attenuated salmonella enterica serovar typhi expressing protective antigen of anthrax toxin (pa83) primes monkeys for accelerated serum antibody responses to parenteral pa83 vaccine. | salmonella enterica serovar typhi vaccine strain cvd 908-htra was genetically engineered for stable plasmid-based expression of protective antigen of anthrax toxin (pa83) fused with the export protein clya (clya-pa83). the priming potential of cvd 908-htra expressing clya-pa83 was assessed in 12 rhesus and 20 cynomolgus macaques that were immunized mucosally (i.e., intranasally) on days 0 and 14. a parenteral booster with purified pa83 plus alum was given to rhesus macaques on days 42 and 225; c ... | 2009 | 19099487 |