| epidemiology of invasive klebsiella pneumoniae with hypermucoviscosity phenotype in a research colony of nonhuman primates. | invasive klebsiella pneumoniae with hypermucoviscosity phenotype (hmv k. pneumoniae) is an emerging human pathogen that, over the past 20 y, has resulted in a distinct clinical syndrome characterized by pyogenic liver abscesses sometimes complicated by bacteremia, meningitis, and endophthalmitis. infections occur predominantly in taiwan and other asian countries, but hmv k. pneumoniae is considered an emerging infectious disease in the united states and other western countries. in 2005, fatal mu ... | 2009 | 20034435 |
| alterations in cytokines and effects of dexamethasone immunosuppression during subclinical infections of invasive klebsiella pneumoniae with hypermucoviscosity phenotype in rhesus (macaca mulatta) and cynomolgus (macaca fascicularis) macaques. | invasive klebsiella pneumoniae with the hypermucoviscosity phenotype (hmv k. pneumoniae) is an emerging human pathogen that also has been attributed to fatal multisystemic disease in african green monkeys at our institution. combining a cluster of subclinically infected macaques identified in march and april 2008 and the animals documented during a subsequent survey of more than 300 colony nonhuman primates yielded a total of 9 rhesus macaques and 6 cynomolgus macaques that were subclinically in ... | 2010 | 20158951 |
| microbicidal activity of octenidine hydrochloride, a new alkanediylbis[pyridine] germicidal agent. | the potential of octenidine hydrochloride (win 41464-2) as a topical microbicide was measured both by in vitro death kinetics and reductions in numbers of bacteria on the skin of cynomolgus monkeys. semilogarithmic survival curves were plotted to measure the microbicidal activity of various concentrations of octenidine against staphylococcus aureus. the microbicidal activity of octenidine was also determined for staphylococcus epidermidis, proteus mirabilis, streptococcus pyogenes, klebsiella pn ... | 1985 | 3909955 |
| structure-activity studies on polymyxin derivatives carrying three positive charges only reveal a new class of compounds with strong antibacterial activity. | recent years have brought in an increased interest to develop improved polymyxins. the currently used polymyxins, i.e. polymyxin b and colistin (polymyxin e) are pentacationic lipopeptides that possess a cyclic heptapeptide part with three positive charges, a linear "panhandle" part with two positive charges, and a fatty acyl tail. unfortunately, their clinical use is shadowed by their notable nephrotoxicity. we have previously developed a polymyxin derivative nab739 which lacks the positive cha ... | 2017 | 28300674 |
| septicemic invasive klebsiella pneumoniae infection in a cynomolgus monkey (macaca fascicularis) with severe diffused suppurative meningoencephalitis. | a 2-year-old male cynomolgus monkey (macaca fascicularis) showed neurological symptoms during quarantine for importation into japan, and was euthanized due to poor prognosis. gross anatomical examination revealed a hemorrhagic lesion around the lateral ventricle in the cerebrum. histologically, severe diffused suppurative meningitis and ventriculitis were detected with numerous gram-negative bacilli in the cerebrum. immunohistochemically, the bacilli were positively stained with an antibody agai ... | 2017 | 28529273 |