Publications

a regional reconnaissance on yellow fever in the sudan; with special reference to primate hosts.	neutralization-tests with yellow fever virus performed on 666 human sera collected in the southern sudan imply that yellow fever is still endemic south of the 10th parallel, in the south-west border of the nuba mountains, and in the plains west of the nuba mountains as far north as el muglad. similar tests on bloods from 110 primates revealed a high rate of immunity among both baboons (papio sp.) (94%) and grivet monkeys (cercopithecus aethiops) (77%), and a very low rate (1 in 56) among galagos ...	1955	14379007
the cyclical transmission of yellow fever virus through the grivet monkey, cercopithecus aethiops centralis neumann, and the mosquito aëdes (stegomyia) africanus theobald.		1950	24539937
global mammal parasite database version 2.0.	illuminating the ecological and evolutionary dynamics of parasites is one of the most pressing issues facing modern science, and is critical for basic science, the global economy, and human health. extremely important to this effort are data on the disease-causing organisms of wild animal hosts (including viruses, bacteria, protozoa, helminths, arthropods, and fungi). here we present an updated version of the global mammal parasite database, a database of the parasites of wild ungulates (artioda ...	2017	28273333
seroprevalence of zika virus in wild african green monkeys and baboons.	zika virus (zikv) has recently spread through the americas and has been associated with a range of health effects, including birth defects in children born to women infected during pregnancy. although the natural reservoir of zikv remains poorly defined, the virus was first identified in a captive "sentinel" macaque monkey in africa in 1947. however, the virus has not been reported in humans or nonhuman primates (nhps) in africa outside gabon in over a decade. here, we examine zikv infection in ...	2017	28289727
host and viral traits predict zoonotic spillover from mammals.	the majority of human emerging infectious diseases are zoonotic, with viruses that originate in wild mammals of particular concern (for example, hiv, ebola and sars). understanding patterns of viral diversity in wildlife and determinants of successful cross-species transmission, or spillover, are therefore key goals for pandemic surveillance programs. however, few analytical tools exist to identify which host species are likely to harbour the next human virus, or which viruses can cross species ...	2017	28636590
serological evidence of zika virus infection in non-human primates in zambia.	zika virus (zikv) circulation occurs between non-human primates (nhps) in a sylvatic transmission cycle. to investigate evidence of flavivirus infection in nhps in zambia, we performed a plaque reduction neutralization test (prnt) to quantify neutralizing antibodies. prnt revealed that sera from nhps (african green monkeys and baboons) exhibited neutralizing activity against zikv (34.4%; 33/96), whereas a prnt for yellow fever virus using nhp sera showed no neutralization activity. zikv genomic ...	2019	31154511
comparative characterization of flavivirus production in two cell lines: human hepatoma-derived huh7.5.1-8 and african green monkey kidney-derived vero.	the flaviviridae is a family of enveloped viruses with a positive-sense single-stranded rna genome. it contains many viruses that threaten human health, such as japanese encephalitis virus (jev) and yellow fever virus (yfv) of the genus flavivirus as well as hepatitis c virus of the genus hepacivirus. cell culture systems highly permissive for the flaviviridae viruses are very useful for their isolation, propagation, and diagnosis, an understanding of their biology, and the development of vaccin ...	2020	32330205
biological characteristics and patterns of codon usage evolution for the african genotype zika virus.	we investigated temporal trends of codon usage changes for different host species to determine their importance in zika virus (zikv) evolution. viral spillover resulting from the potential of codon adaptation to host genome was also assessed for the african genotype zikv in comparison to the asian genotype. to improve our understanding on its zoonotic maintenance, we evaluated in vitro the biological properties of the african genotype zikv in vertebrate and mosquito cell lines. analyses were per ...	2020	33202554
dengue, yellow fever, zika and chikungunya epidemic arboviruses in brazil: ultrastructural aspects.	the impact of arbovirus cocirculation in brazil is unknown. dengue virus (denv) reinfection may result in more intense viraemia or immunopathology, leading to more severe disease. the zika virus (zikv) epidemic in the americas provided pathogenicity evidence that had not been previously observed in flavivirus infections. in contrast to other flaviviruses, electron microscopy studies have shown that zikv may replicate in viroplasm-like structures. flaviviruses produce an ensemble of structurally ...	2021	33566939