Publications

TitleAbstractYear
Filter
PMID
Filter
schistosomiasis in omo national park of southwest ethiopia.schistosomiasis mansoni infection was found in more than 50 tourists who had visited omo national park, ethiopia, and bathed and swum in the mui river. a survey revealed schistosoma mansoni infection in 41% of park residents and in 33% of the neighboring suri people. eggs were found in stools and adult worms at autopsy of wild papio anubis and cercopithecus aethiops. trematode larvae were found in 27% of biomphalaria pfeifferi snails found in the mui river. the source of the disease and the impl ...1979110163
efficacy of a new hoffmann-la roche compound (ro 15-5458) against schistosoma mansoni (gezira strain, sudan) in vervet monkeys (cercopithecus aethiops).some compounds of the class 9-acridanone-hydrazones have recently been developed by hoffmann-la roche (basel-switzerland) and were shown to have antischistosomal effects. one of these compounds (ro 15-5458/000) was administered at two dose levels (25 mg and 15 mg/kg body-weight) to s. mansoni (gezira strain-sudan) infected vervet monkeys. the faecal egg-output was terminated, worm-burden killed and tissue egg-counts were greatly reduced as compared with the untreated control monkey. severe necro ...19892515579
[a comparison of the pathogenicity of two strains of schistosoma mansoni in cercopithecus aethiops monkeys in the sudan]. 19744214855
experimental schistosoma mansoni infections in vervet monkeys (cercopithecus aethiops centralis). 19724623246
experimental schistosomiasis in primates in tanzania. i. a preliminary note on the susceptibility of cercopithecus aethiops centralis to infection with schistosoma haematobium and schistosoma mansoni. 19664960090
protection against schistosoma mansoni and associated immune responses induced in the vervet monkey cercopithecus aethiops by the irradiated cercaria vaccine.the efficacy of the radiation-attenuated schistosome vaccine in eliciting protective immunity was investigated in the vervet cercopithecus aethiops. three groups of test animals received one, three, or five exposures to 5,000-9,000 cercariae attenuated with 30 krad of gamma radiation from a 137cs source, while a fourth group served as challenge controls. after a single vaccination, no statistically significant protection was found; after three vaccinations it reached its highest peak (48%) and f ...19968600763
some gastro-intestinal parasites of zoonotic (public health) importance commonly observed in old world non-human primates in kenya.a study was undertaken to categorise some gastro-intestinal (git) parasites commonly observed in kenyan non-human primates (nhps) on the basis of their health implications for humans. six species of locally available non-human primates, namely olive baboons (papio cyanocephalus anubis), vervet monkey (cercopithecus aethiops), sykes monkey (cercopithecus mitis), black and white colobus (colobus abyssinicus), debrazzas monkey (cercopithecus neglectus) and grey and black mangabeys (cercocebus torqu ...19989776144
the nature of flurescent antibody reactions in infections and artificial immunizations with schistosoma mansoni.this paper describes studies in which schistosoma mansoni eggs, miracidia, cercariae, schistosomula and adults were fixed with formol and stained with antibodies labelled with fluorescein isothiocyanate. the cuticle of the cercariae, cuticle of the schistosomula and ciliated epithelium of the miracidia were consistently and specifically reactive with labelled immune serum. in cercariae fixed with acetic acid and subsequently treated with immune serum followed by exposure to labelled antispecies ...196214037613
experimental schistosoma mansoni infection in vervet monkeys (cercopithecus aethiops) in kenya: i. susceptibility to a primary infection.groups of five 3-kg kenyan monkeys, cercopithecus aethiops, were exposed individually to 150,600 or 1500 schistosoma mansoni cercariae per monkey. three monkeys died soon after the infections became patent and the survivors were autopsied 4 months after exposure. mortality and most haematological, parasitological and pathological sequelae of infection were dose-related, but not the white cell response or changes in the levels of serum proteins or fibrinogen. no gross liver fibrosis was seen. com ...19846747261
long-term infection of schistosoma mansoni in a vervet monkey (cercopithecus aethiops).schistosoma mansoni infection in cercopithecus species monkeys has been previously monitored for up to five years. this is an account of observations made during an autopsy on a male vervet monkey which had harboured the parasite for 15 years. viable eggs had been recovered from the faeces throughout the infection, being hatched to observe the emergence of miracidia. apart from a nodular appearance of the liver capsule, which was noted before the perfusion, and localized haemorrhaging in the lar ...19836679365
single and repeated infections of grivet monkeys with schistosoma mansoni: parasitological and pathological observations over a 31-month period.groups of 6 to 8 grivet monkeys (ceropithecus aethiops aethiops), each of which had been exposed to 600 cercariae of schistosoma mansoni, were killed 3, 6, and 31 months after exposure. other groups of monkeys were repeatedly challenged with cercariae beginning 4 or 23 months after the initial infection, and were killed 31 months after the first exposure. peripheral blood leukocytes, eosinophiles, and schistosome eggs passed in the feces were determined during the course of the infection. at aut ...19744217568
vaccination of the vervet monkey (cercopithecus aethiops) against infection with schistosoma mansoni.pilot experiments were carried out to assess the immunizing potential of radiation-attenuated cercariae of s. mansoni. groups of 4 monkeys each were vaccinated 4-5 times at 3-5-week intervals using cercariae which had received 10, 20, 40 or 60 krad of gamma radiation. animals were vaccinated with 1000 or 2000 cercariae per kilogram of body weight. overall the difference in worm burdens between the vaccinated and unvaccinated groups was highly significant (p greater than 0.01). the highest level ...19921514046
the development of hepatic granulomas in 20 krad irradiated schistosoma mansoni cercaria vaccinated grivet monkeys (cercopithecus aethiops aethiops).the absence of appropriate animal models is a challenge for those designing anti-schistosome vaccines. in order to observe the development of hepatic granulomata, 20 krad irradiated cercaria vaccinated grivet monkeys (cercopithecus aethiops aethiops) were experimentally infected with schistosoma mansoni. most human clinical manifestations of schistosomiasis were noted in the infected monkeys. intraperitonial immunization with 20 krad irradiated cercaria resulted in a relatively less granulomatou ...200717603044
serum cytokines of the 20 krad-irradiated s. mansoni cercariae vaccinated, primary and superinfected cercopethicus aethiops aethiops.appropriate animal models are necessary to better understand the immune response in schistosomiasis. schistosoma mansoni infection was established using irradiated cercariae in cercopithecus aethiops aethiops (grivet monkey) to describe immune responses of the serum cytokines, il-4, il-10, il-12, ifn- gamma, and tnf-alpha. intraperitoneal irradiated cercariae immunization on three occasions resulted in some differences of cytokine production. in primary infection, il-4 was significantly raised ( ...200716949577
zoonotic intestinal parasites in papio anubis (baboon) and cercopithecus aethiops (vervet) from four localities in ethiopia.a total of 59 faecal samples from ranging papio anubis (baboons) and another 41 from cercopithecus aethiops (vervet) from the rift valley areas of ethiopia were microscopically examined to determine the prevalence and species of major gastro-intestinal parasites of zoonotic importance. faecal smears were prepared from fresh faecal samples, stained using modified ziehl-neelsen method and microscopically examined. about 3 gm of the dropping was also preserved separately in clean and properly label ...200415099809
schistosoma mansoni in baboons. iii. the course and characteristics of infection, with additional observations on immunity.parasitological, clinical, and histopathological observations on 54 baboons infected with schistosoma mansoni are presented. the baboon and s. mansoni constitute a compatible host-parasite system, evidence by the infectivity of cercariae (98% penetration, 42% adult worm recovery), and the long, fertile life of the worms. baboons tolerated the infection well, with clinical illness a rarity in moderately infected baboons. pathological findings were generally unremarkable. an acute "toxemic" phase ...1976816218
Displaying items 1 - 16 of 16