canine hepacivirus ns3 serine protease can cleave the human adaptor proteins mavs and trif.canine hepacivirus (chv) was recently identified in domestic dogs and horses. the finding that chv is genetically the virus most closely related to hepatitis c virus (hcv) has raised the question of whether hcv might have evolved as the result of close contact between dogs and/or horses and humans. the aim of this study was to investigate whether the ns3/4a serine protease of chv specifically cleaves human mitochondrial antiviral signaling protein (mavs) and toll-il-1 receptor domain-containing ...201222870331
characterization of a canine homolog of hepatitis c estimated 3% of the world's population is chronically infected with hepatitis c virus (hcv). although hcv was discovered more than 20 y ago, its origin remains obscure largely because no closely related animal virus homolog has been identified; furthermore, efforts to understand hcv pathogenesis have been hampered by the absence of animal models other than chimpanzees for human disease. here we report the identification in domestic dogs of a nonprimate hepacivirus. comparative phylogenetic an ...201121610165
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