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from nerves to brain to gastrointestinal tract: a time-based study of parrot bornavirus 2 (pabv-2) pathogenesis in cockatiels (nymphicus hollandicus).parrot bornaviruses (pabvs) are the causative agents of proventricular dilatation disease, however key aspects of its pathogenesis, such as route of infection, viral spread and distribution, and target cells remain unclear. our study aimed to track the viral spread and lesion development at 5, 10, 20, 25, 35, 40, 60, 80, 95 and 114 dpi using histopathology, immunohistochemistry, and rt-pcr. after intramuscular inoculation of parrot bornavirus 2 (pabv-2) in the pectoral muscle of cockatiels, this ...201729121071
viral vector vaccines protect cockatiels from inflammatory lesions after heterologous parrot bornavirus 2 challenge infection.avian bornaviruses are causative agents of proventricular dilatation disease (pdd), a chronic neurologic and often fatal disorder of psittacines including endangered species. to date no causative therapy or immunoprophylaxis is available. our previous work has shown that viral vector vaccines can delay the course of homologous bornavirus challenge infections but failed to protect against pdd when persistent infection was not prevented. the goal of this study was to refine our avian bornavirus va ...201728017426
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