fetal brain lesions after subcutaneous inoculation of zika virus in a pregnant nonhuman primate.we describe the development of fetal brain lesions after zika virus (zikv) inoculation in a pregnant pigtail macaque. periventricular lesions developed within 10 d and evolved asymmetrically in the occipital-parietal lobes. fetal autopsy revealed zikv in the brain and significant cerebral white matter hypoplasia, periventricular white matter gliosis, and axonal and ependymal injury. our observation of zikv-associated fetal brain lesions in a nonhuman primate provides a model for therapeutic eval ...201627618651
congenital zika virus infection as a silent pathology with loss of neurogenic output in the fetal brain.zika virus (zikv) is a flavivirus with teratogenic effects on fetal brain, but the spectrum of zikv-induced brain injury is unknown, particularly when ultrasound imaging is normal. in a pregnant pigtail macaque (macaca nemestrina) model of zikv infection, we demonstrate that zikv-induced injury to fetal brain is substantial, even in the absence of microcephaly, and may be challenging to detect in a clinical setting. a common and subtle injury pattern was identified, including (i) periventricular ...201829400709
early cellular innate immune responses drive zika viral persistence and tissue tropism in pigtail macaques.the immunological and virological events that contribute to the establishment of zika virus (zikv) infection in humans are unclear. here, we show that robust cellular innate immune responses arising early in the blood and tissues in response to zikv infection are significantly stronger in males and correlate with increased viral persistence. in particular, early peripheral blood recruitment of plasmacytoid dendritic cells and higher production of monocyte chemoattractant protein (mcp-1) correspo ...201830135445
Displaying items 1 - 3 of 3