Publications

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development of a zika virus infection model in cynomolgus macaques.limited availability of indian rhesus macaques (irm) is a bottleneck to study zika virus (zikv) pathogenesis and evaluation of appropriate control measures in non-human primates. to address these issues, we report here the mauritian cynomolgus macaque (mcm) model for zikv infection. in brief, six mcms (seronegative for dengue and zikv) were subdivided into three cohorts with a male and female each and challenged with different doses of asian [prvabc59 (puerto rico) or fss13025 (cambodia)] or afr ...201628066354
high infection rates for adult macaques after intravaginal or intrarectal inoculation with zika virus.unprotected sexual intercourse between persons residing in or traveling from regions with zika virus transmission is a risk factor for infection. to model risk for infection after sexual intercourse, we inoculated rhesus and cynomolgus macaques with zika virus by intravaginal or intrarectal routes. in macaques inoculated intravaginally, we detected viremia and virus rna in 50% of macaques, followed by seroconversion. in macaques inoculated intrarectally, we detected viremia, virus rna, or both, ...201728548637
zika viral dynamics and shedding in rhesus and cynomolgus macaques.infection with zika virus has been associated with serious neurological complications and fetal abnormalities. however, the dynamics of viral infection, replication and shedding are poorly understood. here we show that both rhesus and cynomolgus macaques are highly susceptible to infection by lineages of zika virus that are closely related to, or are currently circulating in, the americas. after subcutaneous viral inoculation, viral rna was detected in blood plasma as early as 1 d after infectio ...201627694931
acute fetal demise with first trimester maternal infection resulting from listeria monocytogenes in a nonhuman primate model.infection with listeria monocytogenes during pregnancy is associated with miscarriage, preterm birth, and neonatal complications, including sepsis and meningitis. while the risk of these conditions is thought to be greatest during the third trimester of pregnancy, the determinants of fetoplacental susceptibility to infection, the contribution of gestational age, and the in vivo progression of disease at the maternal-fetal interface are poorly understood. we developed a nonhuman primate model of ...201728223455
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