Publications

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serologic evidence of yersinia pestis infection in small mammals and bears from a temperate rainforest of north coastal california.from 1983 to 1985, 463 serum samples from 11 species of mammals in redwood national park (rnp) (california, usa) were evaluated for antibodies to yersinia pestis by the passive hemagglutination method. yersinia pestis antibodies occurred in serum samples from 25 (36%) of 69 black bears (ursus americanus), one (50%) of two raccoons (procyon lotor), five (3%) of 170 dusky-footed woodrats (neotoma fuscipes), and one (less than 1%) of 118 deer mice (peromyscus maniculatus). two hundred seventy-three ...19892915403
a recombinant raccoon poxvirus vaccine expressing both yersinia pestis f1 and truncated v antigens protects animals against lethal plague.in previous studies, we demonstrated in mice and prairie dogs that simultaneous administration of two recombinant raccoon poxviruses (rrcn) expressing yersinia pestis antigens (f1 and v307-a truncated version of the v protein) provided superior protection against plague challenge compared to individual single antigen constructs. to reduce costs of vaccine production and facilitate implementation of a sylvatic plague vaccine (spv) control program for prairie dogs, a dual antigen construct is more ...201426344891
limited infection upon human exposure to a recombinant raccoon pox vaccine vector.a laboratory accident resulted in human exposure to a recombinant raccoon poxvirus (rcn) developed as a vaccine vector for antigens of yersinia pestis for protection of wild rodents (and other animals) against plague. within 9 days, the patient developed a small blister that healed within 4 weeks. raccoon poxvirus was cultured from the lesion, and the patient developed antibody to plague antigen (f1) and rcn. this is the first documented case of human exposure to rcn.200415246608
recombinant raccoon pox vaccine protects mice against lethal plague.using a raccoon poxvirus (rcn) expression system, we have developed new recombinant vaccines that can protect mice against lethal plague infection. we tested the effects of a translation enhancer (emcv-ires) in combination with a secretory (tpa) signal or secretory (tpa) and membrane anchoring (chv-gg) signals on in vitro antigen expression of f1 antigen in tissue culture and the induction of antibody responses and protection against yersinia pestis challenge in mice. the rcn vector successfully ...200312559803
consumption of baits containing raccoon pox-based plague vaccines protects black-tailed prairie dogs (cynomys ludovicianus).baits containing recombinant raccoon poxvirus (rcn) expressing plague antigens (fraction 1 [f1] and a truncated form of the v protein-v307) were offered for voluntary consumption several times over the course of several months to a group of 16 black-tailed prairie dogs (cynomys ludovicianus). for comparison, another group of prairie dogs (n = 12) was injected subcutaneously (sc) (prime and boost) with 40 microg of f1-v fusion protein absorbed to alum, a vaccine-adjuvant combination demonstrated ...201020158332
further development of raccoon poxvirus-vectored vaccines against plague (yersinia pestis).in previous studies, we demonstrated protection against plague in mice and prairie dogs using a raccoon pox (rcn) virus-vectored vaccine that expressed the f1 capsular antigen of yersinia pestis. in order to improve vaccine efficacy, we have now constructed additional rcn-plague vaccines containing two different forms of the lcrv (v) gene, including full-length (vfull) and a truncated form (v307). mouse challenge studies with y. pestis strain co92 showed that vaccination with a combination of rc ...200919879228
immunization of black-tailed prairie dog against plague through consumption of vaccine-laden baits.prairie dogs (cynomys spp.) are highly susceptible to yersinia pestis and, along with other wild rodents, are significant reservoirs of plague for other wildlife and humans in the western united states. a recombinant raccoon poxvirus, expressing the f1 antigen of y. pestis, was incorporated into a palatable bait and offered to three groups (n = 18, 19, and 20) of black-tailed prairie dogs (cynomys ludovicianus) for voluntary consumption, either one, two, or three times, at roughly 3-wk intervals ...200818957649
protection of black-tailed prairie dogs (cynomys ludovicianus) against plague after voluntary consumption of baits containing recombinant raccoon poxvirus vaccine.prairie dogs (cynomys spp.) are highly susceptible to yersinia pestis and significant reservoirs of plague for humans in the western united states. a recombinant raccoon poxvirus, expressing the f1 antigen of y. pestis, was incorporated into a palatable bait and offered to 18 black-tailed prairie dogs (cynomys ludovicianus) for voluntary consumption; 18 negative control animals received placebo baits. antibody titers against y. pestis f1 antigen increased significantly (p < 0.01) in vaccinees, a ...200415322054
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