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gastric colonization of the ferret with helicobacter species: natural and experimental infections.helicobacter mustelae, isolated from the stomachs of adult ferrets, appears to have a world-wide distribution. ferrets are colonized with h. mustelae at a young age, usually 5-6 weeks; in our experience 100% of adult ferrets are colonized in both the antrum and the fundus. gastric infection correlates with elevation of serum igg antibodies to h. mustelae. in the oxyntic mucosa the presence of superficial gastritis coincides closely with the presence of h. mustelae. in the distal antrum the organ ...19911833810
gastric helicobacter spp. in animal models: pathogenesis and modulation by extragastric coinfections.animal models are used to study complex host, microbial, and environmental influences associated with gastric helicobacter infection. evidence that gastric helicobacters are pathogenic in animals first came from ferrets. felids, nonhuman primates, and many other species also harbor stomach helicobacters. today, mice are preferred by most researchers for scientific investigation because of cost-efficiencies, rapid reproduction, choice of laboratory reagents, and availability of genetically engine ...201223015504
nonprimate animal models of h. pylori infection.ever since the realization that helicobacter pylori was intimately associated with the development of gastritis and peptic ulcer disease in humans, there has been a need for a simple animal model in which modes of pathogenicity, transmission, immunization, and chemotherapeutic intervention can be evaluated. whereas small animals such as mice and rats are particularly well suited as experimental hosts for many infections, early studies suggested that h. pylori had a very narrow host range that di ...199721351037
gastric bacteria other than helicobacter pylori.since the culture of helicobacter pylori from the human stomach in 1983 there has been renewed interest in other bacteria that had been observed in animal stomachs as early as late in the nineteenth century. many of these bacteria have now been isolated and have been shown to belong to the same genus, helicobacter, which currently contains nine species. study of the gastric helicobacters is important because it provides relevant information about how bacteria can survive in the gastric environme ...19938449568
helicobacter animal models.in this unit, protocols for growing helicobacter organisms on plates or in liquid cultures are presented, followed by protocols for infecting mice with helicobacter felis and h. pylori and for infecting ferrets with h. mustelae. also, a procedure is described for adapting an h. pylori isolate to growth in mice. support protocols describe methods for quantifying numbers of helicobacter organisms, and how to create a growth curve for helicobacter cultures. one important technique in investigating ...200118432759
animal models and vaccine development.following the demonstration of helicobacter pylori as a major gastroduodenal pathogen there was a need to develop animal models in order to investigate mechanisms of pathogenesis and to be able to test new treatment strategies. helicobacter pylori will only colonize a limited number of hosts including non-human primates, germ-free or barrier raised piglets, germ-free dogs and recently laboratory raised cats. although these models have proved useful there is a need for more convenient small anima ...19958563056
identification and molecular characterization of a major ring-forming surface protein from the gastric pathogen helicobacter mustelae.the spiral microaerophilic bacterium helicobacter mustelae is linked to gastritis and gastric ulcers in ferrets. electron microscopy of h. mustelae showed the presence of a laterally extensive array of 8.5-nm-diameter rings on the cell surface, which was shown to be composed of a 150kda protein. this protein was purified, and the sequence of 10 amino-terminal residues was determined. polyclonal antibody against the purified 150 kda protein labelled the ring structures on the homologous strain by ...19948170397
helicobacter infections in laboratory animals: a model for gastric neoplasias?evidence is rapidly accumulating that helicobacter pylori is a major risk factor for human gastric adenocarcinomas and all low-grade b-cell gastric lymphomas. given this, there is a need to develop animal models with a view to discovering not only how carcinogenesis is initiated, but also how the process can be prevented. the lack of h. pylori animal models suitable for long-term studies means that alternatives are needed. the most productive models are likely to be the helicobacter mustelae-inf ...19958541035
therapeutic immunization against helicobacter mustelae in naturally infected ferrets.helicobacter infection of the gastric antrum is responsible for a number of gastric disorders. antibiotic therapy is lengthy and is not always effective. it has been shown previously that oral immunization against helicobacter felis in mice can prevent colonization after challenge. the aim of this study was to investigate the efficacy of therapeutic immunization in eradicating an established helicobacter infection and in reducing gastritis.19968964402
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