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broad-spectrum inhibitors against 3c-like proteases of feline coronaviruses and feline caliciviruses.feline infectious peritonitis and virulent, systemic calicivirus infection are caused by certain types of feline coronaviruses (fcovs) and feline caliciviruses (fcvs), respectively, and are important infectious diseases with high fatality rates in members of the felidae family. while fcov and fcv belong to two distinct virus families, the coronaviridae and the caliciviridae, respectively, they share a dependence on viral 3c-like protease (3clpro) for their replication. since 3clpro is functional ...201525694593
x-ray structure and inhibition of the feline infectious peritonitis virus 3c-like protease: structural implications for drug design.feline infectious peritonitis (fip) is a deadly disease that effects both domestic and wild cats and is caused by a mutation in feline coronavirus (fcov) that allows the virus to replicate in macrophages. currently, there are no treatments or vaccines available for the treatment of fip even though it kills approximately 5% of cats in multi-cat households per year. in an effort to develop small molecule drugs targeting fip for the treatment of cats, we screened a small set of designed peptidomime ...201526592814
characterization of amino acid substitutions in feline coronavirus 3c-like protease from a cat with feline infectious peritonitis treated with a protease inhibitor.feline infectious peritonitis (fip) is a highly fatal disease caused by a virulent feline coronavirus in domestic and wild cats. we have previously reported the synthesis of potent coronavirus 3c-like protease (3clpro) inhibitors and the efficacy of a protease inhibitor, gc376, in client-owned cats with fip. in this study, we studied the effect of the amino acid changes in 3clpro of feline coronavirus from a feline patient who received antiviral treatment for prolonged duration. we generated rec ...201931585653
pathogenesis of oral type i feline infectious peritonitis virus (fipv) infection: antibody-dependent enhancement infection of cats with type i fipv via the oral route.feline infectious peritonitis virus (fipv) causes a severe, immune-mediated disease called fip in domestic and wild cats. it is unclear whether fip transmits from cat to cat through the oral route of fipv infection, and the reason for this includes that fip is caused by oral inoculation with some fipv strains (e.g., type ii fipv wsu 79-1146), but is not caused by other fipv (e.g., type i fipv ku-2 strain: fipv-i ku-2). in this study, when cats passively immunized with anti-fipv-i ku-2 antibodies ...201931019150
effect of chloroquine on feline infectious peritonitis virus infection in vitro and in vivo.feline infectious peritonitis (fip) is a feline coronavirus-induced fatal disease in domestic and wild cats. several studies have investigated potential treatments for fip. however, there have been no reports on agents that have exhibited a therapeutic effect. recently, chloroquine has been reported to antiviral effect. we investigated whether chloroquine can be used to treat fip in vitro and in vivo. it was demonstrated that chloroquine has inhibitory effect against the replication of fipv and ...201323648708
generation, characterization and therapeutic potential of anti-feline tnf-alpha mabs for feline infectious peritonitis.feline infectious peritonitis (fip) is a lethal infectious disease affecting domestic and wild cats. several reports suggested that tnf-alpha is related to the progression of fip. thus, the administration of a feline tnf-alpha-neutralizing antibody to cats with fip may reduce the disease progression. in this study, we have prepared nine monoclonal antibodies (mabs) that recognize feline tnf-alpha. all mabs neutralized recombinant tnf-alpha. the 50% inhibitory concentrations (ic50) of the mabs fo ...201324095161
evaluation of protective efficacy of the synthetic peptide vaccine containing the t-helper 1 epitope with cpg oligodeoxynucleotide against feline infectious peritonitis virus infection in cats.feline infectious peritonitis (fip) is a feline coronavirus-induced fatal disease in domestic and wild cats. cellular immunity is considered to play an important role in the prevention of fip. thus, induction of the cellular immune response is essential in vaccines against fip virus (fipv) infection.201424458025
neutrophil survival factors (tnf-alpha, gm-csf, and g-csf) produced by macrophages in cats infected with feline infectious peritonitis virus contribute to the pathogenesis of granulomatous lesions.feline infectious peritonitis (fip) is a feline coronavirus (fcov)-induced fatal disease of domestic and wild cats. the infiltration of neutrophils into granulomatous lesions is unusual for a viral disease, but it is a typical finding of fip. this study aimed to investigate the reason for the lesions containing neutrophils in cats with fip. neutrophils of cats with fip were cultured, and changes in the cell survival rate were assessed. in addition, the presence or absence of neutrophil survival ...200919343474
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