Publications

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retrovirus infections in non-domestic felids: serological studies and attempts to isolate a lentivirus.an african lioness from the zoo of zurich had to be euthanized because of an inoperable tumor. the serum tested negative for feline leukemia virus (felv) p27 antigen by enzyme-linked immunosorbent assay (elisa) but was strongly positive for feline immunodeficiency virus (fiv) antibodies by elisa and western blot. when her only offspring and mate were tested for fiv, high antibody titers to fiv were also found in their serum. lymphocytes were prepared from these two lions on different occasions a ...19921337398
serosurvey of viral infections in free-ranging namibian cheetahs (acinonyx jubatus).cheetahs (acinonyx jubatus) in captivity have unusually high morbidity and mortality from infectious diseases, a trait that could be an outcome of population homogeneity or the immunomodulating effects of chronic stress. free-ranging namibian cheetahs share ancestry with captive cheetahs, but their susceptibility to infectious diseases has not been investigated. the largest remaining population of free-ranging cheetahs resides on namibian farmlands, where they share habitat with domestic dogs an ...200415137485
solitary t-cell hepatic lymphoma with large granular lymphocyte morphology in a captive cheetah (acinonyx jubatus).a 13-yr-old male cheetah (acinonyx jubatus) presented for an acute history of lateral recumbency and anorexia. upon physical examination under general anesthesia, severe icterus was noted. a serum biochemical profile confirmed markedly elevated total bilirubin and alanine transaminase. based on ultrasound-guided liver aspirates and cytology, a presumptive diagnosis of large granular lymphocyte hepatic lymphoma was reached. abdominal and thoracic radiographs did not assist in reaching an antemort ...201526056904
multicentric t-cell lymphoma and cutaneous hemangiosarcoma in a captive cheetah (acinonyx jubatus).a 13-yr-old intact male cheetah (acinonyx jubatus) presented for evaluation after a 4-mo history of intermittent lethargy and increased expiratory effort. the clinical signs were initially noted after the diagnosis and death of its 13-yr-old male sibling with solitary hepatic t-cell lymphoma. physical examination findings included thin body condition, harsh lung sounds, peripheral lymphadenopathy, and a cutaneous mass on the right medial tarsus and scrotum. excisional biopsies diagnosed well-dif ...201526667562
gammaretrovirus-specific antibodies in free-ranging and captive namibian cheetahs.the cheetah population in namibia is the largest free-ranging population in the world and a key population for research regarding the health status of this species. we used serological methods and quantitative real-time pcr to test free-ranging and captive namibian cheetahs for the presence of feline leukemia virus (felv), a gammaretrovirus that can be highly aggressive in populations with low genetic diversity, such as cheetahs. we also assessed the presence of antibodies to other gammaretrovir ...201525809630
seroprevalences to viral pathogens in free-ranging and captive cheetahs (acinonyx jubatus) on namibian farmland.cheetah populations are diminishing rapidly in their natural habitat. one reason for their decline is thought to be a high susceptibility to (infectious) diseases because cheetahs in zoos suffer from high disease-induced mortality. data on the health status of free-ranging cheetahs are scarce, and little is known about their exposure and susceptibility to infectious diseases. we determined seroprevalences to nine key viruses (feline herpesvirus 1, feline calicivirus, feline parvovirus, feline co ...201019955325
multicentric t-cell lymphoma associated with feline leukemia virus infection in a captive namibian cheetah (acinonyx jubatus).this case report describes a multicentric lymphoma in a 4 yr old female wildborn captive cheetah (acinonyx jubatus) in namibia after being housed in an enclosure adjacent to a feline leukemia virus (felv) infected cheetah that had previously been in contact with domestic cats. the year prior to the onset of clinical signs, the wild-born cheetah was felv antigen negative. the cheetah subsequently developed lymphoma, was found to be infected with felv, and then rapidly deteriorated and died. at ne ...200314567232
feline leukemia virus infection in a captive cheetah and the clinical and antibody response of six captive cheetahs to vaccination with a subunit feline leukemia virus vaccine. 19862851578
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