Publications

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evidence for an ancestral association of human coronavirus 229e with bats.we previously showed that close relatives of human coronavirus 229e (hcov-229e) exist in african bats. the small sample and limited genomic characterizations have prevented further analyses so far. here, we tested 2,087 fecal specimens from 11 bat species sampled in ghana for hcov-229e-related viruses by reverse transcription-pcr (rt-pcr). only hipposiderid bats tested positive. to compare the genetic diversity of bat viruses and hcov-229e, we tested historical isolates and diagnostic specimens ...201526378164
experimental infection and response to rechallenge of alpacas with middle east respiratory syndrome coronavirus.we conducted a challenge/rechallenge trial in which 3 alpacas were infected with middle east respiratory syndrome coronavirus. the alpacas shed virus at challenge but were refractory to further shedding at rechallenge on day 21. the trial indicates that alpacas may be suitable models for infection and shedding dynamics of this virus.201627070733
infection, replication, and transmission of middle east respiratory syndrome coronavirus in alpacas.middle east respiratory syndrome coronavirus is a recently emerged pathogen associated with severe human disease. zoonotic spillover from camels appears to play a major role in transmission. because of logistic difficulties in working with dromedaries in containment, a more manageable animal model would be desirable. we report shedding and transmission of this virus in experimentally infected alpacas (n = 3) or those infected by contact (n = 3). infectious virus was detected in all infected anim ...201627070385
mers-cov infection of alpaca in a region where mers-cov is endemic. 201627070501
middle east respiratory syndrome coronavirus (mers-cov) origin and animal reservoir.middle east respiratory syndrome-coronavirus (mers-cov) is a novel coronavirus discovered in 2012 and is responsible for acute respiratory syndrome in humans. though not confirmed yet, multiple surveillance and phylogenetic studies suggest a bat origin. the disease is heavily endemic in dromedary camel populations of east africa and the middle east. it is unclear as to when the virus was introduced to dromedary camels, but data from studies that investigated stored dromedary camel sera and geogr ...201627255185
isolation and characterization of dromedary camel coronavirus uae-hku23 from dromedaries of the middle east: minimal serological cross-reactivity between mers coronavirus and dromedary camel coronavirus uae-hku23.recently, we reported the discovery of a dromedary camel coronavirus uae-hku23 (dccov uae-hku23) from dromedaries in the middle east. in this study, dccov uae-hku23 was successfully isolated in two of the 14 dromedary fecal samples using hrt-18g cells, with cytopathic effects observed five days after inoculation. northern blot analysis revealed at least seven distinct rna species, corresponding to predicted subgenomic mrnas and confirming the core sequence of transcription regulatory sequence mo ...201627164099
middle east respiratory syndrome coronavirus experimental transmission using a pig model.dromedary camels are the main reservoir of middle east respiratory syndrome coronavirus (mers-cov), but other livestock species (i.e., alpacas, llamas, and pigs) are also susceptible to infection with mers-cov. animal-to-animal transmission in alpacas was reported, but evidence for transmission in other species has not been proved. this study explored pig-to-pig mers-cov transmission experimentally. virus was present in nasal swabs of infected animals, and limited amounts of viral rna, but no in ...201728653496
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