resistance to innate immunity contributes to colonization of the insect gut by yersinia pestis.yersinia pestis, the causative agent of bubonic and pneumonic plague, is typically a zoonotic vector-borne disease of wild rodents. bacterial biofilm formation in the proventriculus of the flea contributes to chronic infection of fleas and facilitates efficient disease transmission. however prior to biofilm formation, ingested bacteria must survive within the flea midgut, and yet little is known about vector-pathogen interactions that are required for flea gut colonization. here we establish a d ...201526177454
infection in a dish: high-throughput analyses of bacterial pathogenesis.diverse aspects of host-pathogen interactions have been studied using non-mammalian hosts such as dictyostelium discoideum, caenorhabditis elegans, drosophila melanogaster and danio rerio for more than 20 years. over the past two years, the use of these model hosts to dissect bacterial virulence mechanisms has been expanded to include the important human pathogens vibrio cholerae and yersinia pestis. innovative approaches using these alternative hosts have also been developed, enabling the isola ...200717178462
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