| the growth of african horse-sickness virus in embryonated hen eggs and the transmission of virus by culicoides variipennis coquillett (diptera, ceratopogonidae). | seven-day-old embryonated hen eggs were infected with african horse sickness virus by the yolk sac and intravenous routes. virus reached a high titre in the blood of infected embryos. culicoides variipennis midges which took a blood meal from infected eggs became infected with virus, and after 7 days at 26 degrees - 27 degrees c transmitted african horse sickness virus to uninfected eggs. c. variipennis may therefore be considered a biological vector of african horse sickness virus in the labora ... | 1975 | 1169930 |
| african horse sickness. | african horse sickness (ahs) is a reportable, noncontagious, arthropod-borne viral disease that results in severe cardiovascular and pulmonary illness in horses. ahs is caused by the orbivirus african horse sickness virus (ahsv), which is transmitted primarily by culicoides imicola in africa; potential vectors outside of africa include culicoides variipennis and biting flies in the genera stomoxys and tabanus. infection with ahsv has a high mortality rate. quick and accurate diagnosis can help p ... | 2011 | 23705175 |
| African horse sickness virus induces apoptosis in cultured mammalian cells. | Infection of mammalian cell cultures with African horse sickness virus (AHSV) is known to result in dramatic cytopathic effects (CPE), but no CPE is observed in infected insect cell cultures despite productive virus replication. The basis for this phenomenon has not yet been investigated, but is suggestive of apoptosis being induced following virus infection of the mammalian cells. To investigate whether AHSV can induce apoptosis in infected mammalian cells, Culicoides variipennis (KC) insect ce ... | 2011 | 21983259 |
| proteolytic cleavage of vp2, an outer capsid protein of african horse sickness virus, by species-specific serum proteases enhances infectivity in culicoides. | purified african horse sickness virus (ahsv) was fed, as part of a blood meal, to adult females from a susceptible colony of culicoides variipennis, established in the insectories at the institute for animal health, pirbright laboratory, uk. the meal consisted of heparinized blood obtained from ovine, bovine, equine (horse and donkey) or canine sources spiked with ahsv serotype 9 (ahsv9). the infectivity levels observed for c. variipennis varied significantly, according to the source of the bloo ... | 1995 | 7595366 |