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noncoding subgenomic flavivirus rna is processed by the mosquito rna interference machinery and determines west nile virus transmission by culex pipiens mosquitoes.flaviviruses, such as zika virus, yellow fever virus, dengue virus, and west nile virus (wnv), are a serious concern for human health. flaviviruses produce an abundant noncoding subgenomic flavivirus rna (sfrna) in infected cells. sfrna results from stalling of the host 5'-3' exoribonuclease xrn1/pacman on conserved rna structures in the 3' untranslated region (utr) of the viral genomic rna. sfrna production is conserved in insect-specific, mosquito-borne, and tick-borne flaviviruses and flavivi ...201627581979
[arboviruses also have an american dream].some arboviruses that originated in the old world have been introduced by humans into the american continent. the first of them was the yellow fever virus, coming from the west african coast with slaves in the 17th-19th centuries, followed by dengue viruses, which were always prevalent within the americas. next was thewest nile virus, introduced in new york in 1999, that spread in only a few years over the whole continent. then, chikungunya virus arrived on saint martin island in 2013 after its ...201728509947
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