francisella genes required for replication in mosquito cells.francisella tularensis, a potential bioterrorism agent, is transmitted by arthropod vectors and causes tularemia in many mammals, including humans. francisella novicida causes disease with similar pathology in mice. we show that f. novicida invades hemocyte-like cells of the sualb cell line derived from anopheles gambiae and replicates vigorously within these cells. we used transposon knockouts of single genes of f. novicida to show that bacterial growth within these insect cells is dependent on ...200819058636
detection of francisella tularensis in alaskan mosquitoes (diptera: culicidae) and assessment of a laboratory model for transmission.tularemia is a zoonotic disease caused by the category a bioterrorism agent francisella tularensis. in scandinavia, tularemia transmission by mosquitoes has been widely cited in the literature. we tested >2,500 mosquitoes captured in alaska and found francisella dna in 30% of pooled samples. to examine the potential for transmission of francisella by mosquitoes, we developed a mosquito model of francisella infection. larvae of anopheles gambiae giles and aedes aegypti (l.) readily ingest f. tula ...201020695280
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