| two loci on chromosome 5 are associated with serum ige levels in labrador retrievers. | crosslinking of immunoglobulin e antibodies (ige) bound at the surface of mast cells and subsequent mediator release is considered the most important trigger for allergic reactions. therefore, the genetic control of ige levels is studied in the context of allergic diseases, such as asthma, atopic rhinitis, or atopic dermatitis (ad). we performed genome-wide association studies in 161 labrador retrievers with regard to total and allergen-specific immunoglobulin e (ige) levels. we identified a gen ... | 2012 | 22720065 |