Publications

induction of neutralizing antibodies in reindeer (rangifer tarandus) after administration of a killed west nile virus vaccine.	in 2002, west nile virus (wnv) infection with clinical neurologic disease and encephalomyelitis was described in reindeer (rangifer tarandus). the susceptibility of reindeer to wnv prompted questions concerning vaccination of reindeer to prevent wnv infection. between january and april 2003, eleven 2-4-yr-old, castrated male reindeer, some of which had antibody titers suggestive of prior exposure to wnv, were vaccinated three times at 4-wk intervals with a commercially available vaccine approved ...	2004	15650096
west nile virus infection in reindeer (rangifer tarandus).	west nile virus (wnv) infection in 4 reindeer (rangifer tarandus) resulted in lymphohistiocytic encephalomyelitis within the medulla oblongata and cervical spinal cord. immunohistochemistry revealed wnv antigen within neurons and among mononuclear cell infiltrates. these represent the first known cases of clinical wnv infection in cervidae. clinical signs and lesions were similar to those described in horses. nucleotide sequence of a 768-bp region of the wnv e-glycoprotein gene revealed 1 nucleo ...	2004	15152836
blood collected on filter paper for wildlife serology: evaluating storage and temperature challenges of field collections.	filter-paper (fp) blood sampling can facilitate wildlife research and expand disease surveillance. previous work indicated that nobuto fp samples from caribou and reindeer (rangifer tarandus subspecies) had comparable sensitivity and specificity to serum samples (≥ 80% for both) in competitive enzyme-linked immunosorbent assays (celisas) for brucella spp., neospora caninum, and west nile virus. the same sensitivity and specificity criteria were met in indirect elisas for brucella spp., bovine he ...	2014	24499329
blood collected on filter paper for wildlife serology: detecting antibodies to neospora caninum, west nile virus, and five bovine viruses in reindeer.	we compared nobuto filter paper (fp) whole-blood samples to serum for detecting antibodies to seven pathogens in reindeer (rangifer tarandus tarandus). serum and fp samples were collected from captive reindeer in 2008-2009. sample pairs (serum and fp eluates) were assayed in duplicate at diagnostic laboratories with the use of competitive enzyme-linked immunosorbent assays (celisas) for neospora caninum and west nile virus (wnv); indirect elisa (ielisas) for bovine herpesvirus type 1 (bhv-1), pa ...	2014	24484497
host and viral traits predict zoonotic spillover from mammals.	the majority of human emerging infectious diseases are zoonotic, with viruses that originate in wild mammals of particular concern (for example, hiv, ebola and sars). understanding patterns of viral diversity in wildlife and determinants of successful cross-species transmission, or spillover, are therefore key goals for pandemic surveillance programs. however, few analytical tools exist to identify which host species are likely to harbour the next human virus, or which viruses can cross species ...	2017	28636590
multi-pathogen serological survey of migratory caribou herds: a snapshot in time.	pathogens can impact host survival, fecundity, and population dynamics even when no obvious disease is observed. few baseline data on pathogen prevalence and diversity of caribou are available, which hampers our ability to track changes over time and evaluate impacts on caribou health. archived blood samples collected from ten migratory caribou herds in canada and two in greenland were used to test for exposure to pathogens that have the potential to effect population productivity, are zoonotic ...	2019	31365561
predicting the global mammalian viral sharing network using phylogeography.	understanding interspecific viral transmission is key to understanding viral ecology and evolution, disease spillover into humans, and the consequences of global change. prior studies have uncovered macroecological drivers of viral sharing, but analyses have never attempted to predict viral sharing in a pan-mammalian context. using a conservative modelling framework, we confirm that host phylogenetic similarity and geographic range overlap are strong, nonlinear predictors of viral sharing among ...	2020	32385239