Publications

the structure of mammalian prions and their aggregates.	prion diseases, such as creutzfeldt-jakob disease in humans, bovine spongiform encephalopathy in cattle, chronic wasting disease in cervids (i.e., deer, elk, moose, and reindeer), and sheep scrapie, are caused by the misfolding of the cellular prion protein (prp(c)) into a disease-causing conformer (prp(sc)). prp(c) is a normal, gpi-anchored protein that is expressed on the surface of neurons and other cell types. the structure of prp(c) is well understood, based on studies of recombinant prp, w ...	2017	28109330
the structure of the infectious prion protein and its propagation.	the prion diseases, which include creutzfeldt-jakob disease in humans, chronic wasting disease in cervids (i.e., deer, elk, moose, and reindeer), bovine spongiform encephalopathy in cattle, as well as sheep and goat scrapie, are caused by the conversion of the cellular prion protein (prp(c)) into a disease-causing conformer (prp(sc)). prp(c) is a regular, gpi-anchored protein that is expressed on the cell surface of neurons and many other cell types. the structure of prp(c) is well studied, base ...	2017	28838667