spongiform encephalopathies in cervidae.the known host range of naturally-occurring transmissible spongiform encephalopathies has expanded in recent years to include wild ruminants. chronic wasting disease (cwd) occurs in mule deer (odocoileus hemionus hemionus) and rocky mountain elk (cervus elaphus nelsoni) in colorado and wyoming, united states of america. these species belong to the family cervidae. cases have occurred primarily in captive animals but a few affected free-ranging animals have been identified. clinical disease in bo ...19921617203
topographic distribution of scrapie amyloid-immunoreactive plaques in chronic wasting disease in captive mule deer (odocoileus hemionus hemionus).chronic wasting disease (cwd), a progressive neurological disorder of captive mule deer, black-tailed deer, hybrids of mule deer and white-tailed deer and rocky mountain elk, is characterized neuropathologically by widespread spongiform change of the neuropil, intracytoplasmic vacuolation in neuronal perikarya and astrocytic hypertrophy and hyperplasia. we report the topographic distribution of amyloid plaques reactive to antibodies prepared against scrapie amyloid in cwd-affected captive mule d ...19911713390
chronic wasting disease of captive mule deer: a spongiform the past 12 years (1967-79) a syndrome we identify as chronic wasting disease has been observed in 53 mule deer (odocoileus hemionus hemionus) and one black-tailed deer (odocoileus hemionus columbianus) held in captivity in several wildlife facilities in colorado and more recently in wyoming. clinical signs were seen in adult deer and included behavioral alterations, progressive weight loss and death in 2 weeks to 8 months. gross necropsy findings included emaciation and excess rumen fluid ad ...19807373730
experimental transmission of chronic wasting disease (cwd) of elk (cervus elaphus nelsoni), white-tailed deer (odocoileus virginianus), and mule deer (odocoileus hemionus hemionus) to white-tailed deer by intracerebral compare clinical and pathologic findings of chronic wasting disease (cwd) in a natural host, 3 groups (n = 5) of white-tailed deer (wtd) fawns were intracerebrally inoculated with a cwd prion of wtd, mule deer, or elk origin. three other uninoculated fawns served as controls. approximately 10 months postinoculation (mpi), 1 deer from each of the 3 inoculated groups was necropsied and their tissues were examined for lesions of spongiform encephalopathy (se) and for the presence of abnormal pri ...200818487485
mule deer spatial association patterns and potential implications for transmission of an epizootic disease.animal social behaviour can have important effects on the long-term dynamics of diseases. in particular, preferential spatial relationships between individuals can lead to differences in the rates of disease spread within a population. we examined the concurrent influence of genetic relatedness, sex, age, home range overlap, time of year, and prion disease status on proximal associations of adult rocky mountain mule deer (odocoileus hemionus hemionus) in a chronic wasting disease endemic area. w ...201728388681
infectious disease and grouping patterns in mule deer.infectious disease dynamics are determined, to a great extent, by the social structure of the host. we evaluated sociality, or the tendency to form groups, in rocky mountain mule deer (odocoileus hemionus hemionus) from a chronic wasting disease (cwd) endemic area in saskatchewan, canada, to better understand factors that may affect disease transmission. using group size data collected on 365 radio-collared mule deer (2008-2013), we built a generalized linear mixed model (glmm) to evaluate wheth ...201627007808
broad and fine-scale genetic analysis of white-tailed deer populations: estimating the relative risk of chronic wasting disease spread.chronic wasting disease is a transmissible spongiform encephalopathy of cervids, similar to sheep scrapie that has only recently been detected in wild populations of white-tailed deer (odocoileus virginianus) and mule deer (odocoileus hemionus hemionus) in western canada. relatively little is known about local transmission dynamics of the disease or the potential for long-distance spread. we analysed the population genetic structure of over 2000 white-tailed deer sampled from alberta, british co ...201125567957
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