prion protein in cardiac muscle of elk (cervus elaphus nelsoni) and white-tailed deer (odocoileus virginianus) infected with chronic wasting investigate the possible presence of disease-associated prion protein (prp(d)) in striated muscle of chronic wasting disease (cwd)-affected cervids, samples of diaphragm, tongue, heart and three appendicular skeletal muscles from mule deer (odocoileus hemionus), white-tailed deer (odocoileus virginianus), elk (cervus elaphus nelsoni) and moose (alces alces shirasi) were examined by elisa, western immunoblot and immunohistochemistry (ihc). prp(d) was detected in samples of heart muscle from se ...200617030881
oral transmission of chronic wasting disease in captive shira's moose.three captive shira's moose (alces alces shirasi) were orally inoculated with a single dose (5 g) of whole-brain homogenate prepared from chronic wasting disease (cwd)-affected mule deer (odocoileus hemionus). all moose died of causes thought to be other than cwd. histologic examination of one female moose dying 465 days postinoculation revealed spongiform change in the neuropil, typical of transmissible spongiform encephalopathy. immunohistochemistry staining for the proteinase-resistant isofor ...200617092895
a natural case of chronic wasting disease in a free-ranging moose (alces alces shirasi).chronic wasting disease (cwd) was diagnosed in a free-ranging moose (alces alces shirasi) killed by a hunter in jackson county, colorado, usa, in september 2005. the diagnosis was based upon immunohistochemistry (ihc) demonstrating the presence of accumulations of cwd-associated prion protein (prp(cwd)) in tissue sections of medulla oblongata at the level of the obex (dorsal motor nucleus of the vagus) and in retropharyngeal lymph node (rpln); additional testing by ihc revealed deposits of prp(c ...200717495319
early detection of chronic wasting disease prions in urine of pre-symptomatic deer by real-time quaking-induced conversion assay.chronic wasting disease (cwd) is a prion disease of captive and free-ranging deer (odocoileus spp), elk (cervus elaphus nelsonii) and moose (alces alces shirasi). unlike in most other prion diseases, in cwd prions are shed in urine and feces, which most likely contributes to the horizontal transmission within and between cervid species. to date, cwd ante-mortem diagnosis is only possible by immunohistochemical detection of protease resistant prion protein (prp (sc) ) in tonsil or recto-anal muco ...201523764839
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