[hantavirus in chile: review and cases analysis since 1975].since the identification of the first case of hantavirus infection in chile in 1995, a great advance in the knowledge of the disease natural history has occurred. there is evidence to suppose that the infection by andes virus in suburban areas of argentina and chile, whose natural reservoir is oligoryzomys longicaudatus, has been present but unidentified for a long time. we describe a serologically proven case occurred in 1975. the clinical presentation of the disease slightly differs from that ...199910835761
complete nucleotide sequence of a chilean hantavirus.we have determined the genomic sequence of an andes virus (andv) strain isolated from an infected oligoryzomys longicaudatus rodent trapped in chile in 1997. this strain, for which we propose the designation chile r123, reproduces essential attributes of hantavirus pulmonary syndrome (hps) when injected intramuscularly into laboratory hamsters (hooper et al., virology 289 (2001) 6-14). the l, m, and s segment sequences of chile r123 are 6562, 3671, and 1871 nt long, respectively, with an overall ...200212367756
transcriptome markers of viral persistence in naturally-infected andes virus (bunyaviridae) seropositive long-tailed pygmy rice rats.long-tailed pygmy rice rats (oligoryzomys longicaudatus) are principal reservoir hosts of andes virus (andv) (bunyaviridae), which causes most hantavirus cardiopulmonary syndrome cases in the americas. to develop tools for the study of the andv-host interactions, we used rna-seq to generate a de novo transcriptome assembly. splenic rna from five rice rats captured in chile, three of which were andv-infected, was used to generate an assembly of 66,173 annotated transcripts, including noncoding rn ...201525856432
rapid enzyme-linked immunosorbent assay for the detection of hantavirus-specific antibodies in divergent small mammals.we assessed the utility of an enzyme-linked immunosorbent assay (elisa) for the detection of hantavirus-specific antibodies from sera of oligoryzomys longicaudatus, the principal reservoir of andes virus (andv), using an antigen previously developed for detection of antibodies to sin nombre virus (snv) in sera from peromyscus maniculatus. the assay uses a protein a/g horseradish peroxidase conjugate and can be performed in as little as 1.5 hours. serum samples from oligoryzomys longicaudatus col ...201424806874
experimental andes virus infection in deer mice: characteristics of infection and clearance in a heterologous rodent world hantaviruses can cause hantavirus cardiopulmonary syndrome with high mortality in humans. distinct virus species are hosted by specific rodent reservoirs, which also serve as the vectors. although regional spillover has been documented, it is unknown whether rodent reservoirs are competent for infection by hantaviruses that are geographically separated, and known to have related, but distinct rodent reservoir hosts. we show that andes virus (andv) of south america, carried by the long ...201323383148
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