Publications

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episodic evolution mediates interspecies transfer of a murine coronavirus.molecular mechanisms permitting the establishment and dissemination of a virus within a newly adopted host species are poorly understood. mouse hepatitis virus (mhv) strains (mhv-a59, mhv-jhm, and mhv-a59/mhv-jhm) were passaged in mixed cultures containing progressively increasing concentrations of nonpermissive syrian baby hamster kidney (bhk) cells and decreasing concentrations of permissive murine dbt cells. from mhv-a59/mhv-jhm mixed infection, variant viruses (mhv-h1 and mhv-h2) which repli ...19979032326
human biliary glycoproteins function as receptors for interspecies transfer of mouse hepatitis virus.a variant mouse hepatitis virus (mhv), designated mhv-h2, was isolated by serial passage in mixed cultures of permissive dbt cells and nonpermissive syrian hamster kidney (bhk) cells. mhv-h2 replicated efficiently in hamster, mouse, primate kidney (vero, cos 1, cos 7), and human adenocarcinoma (hrt) cell lines but failed to replicate in porcine testicular (st), feline kidney (crfk), and canine kidney (mdck) cells. to understand the molecular basis for coronavirus cross-species transfer into huma ...19989782263
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