Publications

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episodic evolution mediates interspecies transfer of a murine coronavirus.molecular mechanisms permitting the establishment and dissemination of a virus within a newly adopted host species are poorly understood. mouse hepatitis virus (mhv) strains (mhv-a59, mhv-jhm, and mhv-a59/mhv-jhm) were passaged in mixed cultures containing progressively increasing concentrations of nonpermissive syrian baby hamster kidney (bhk) cells and decreasing concentrations of permissive murine dbt cells. from mhv-a59/mhv-jhm mixed infection, variant viruses (mhv-h1 and mhv-h2) which repli ...19979032326
virus-receptor interactions and interspecies transfer of a mouse hepatitis virus.molecular mechanisms regulating virus xenotropism and cross-species transmission are poorly understood. host range mutants (mhv-h2) of mouse hepatitis virus (mhv) strains were isolated from mixed cultures containing progressively increasing concentrations of nonpermissive syrian baby hamster kidney (bhk) cells and decreasing concentrations of permissive murine astrocytoma (dbt) cells. mhv-h2 was polytrophic, replicating efficiently in normally nonpermissive bhk cells, syrian and chinese hamster ...19989782262
persistent infection promotes cross-species transmissibility of mouse hepatitis virus.persistent infection with mouse hepatitis virus (mhv) strain a59 in murine dbt (delayed brain tumor) cells resulted in the emergence of host range variants, designated v51a and v51b, at 210 days postinfection. these host range mutants replicated efficiently in normally nonpermissive chinese hamster ovary (cho), in human hepatocarcinoma (hepg2), and to a lesser extent in human breast carcinoma (mcf7) cell lines. little if any replication was noted in baby hamster kidney (bhk), green african monke ...19999847369
the nucleocapsid protein of murine hepatitis virus type 3 induces transcription of the novel fgl2 prothrombinase gene.using a set of parental and recombinant murine hepatitis virus strains, we demonstrate that the nucleocapsid protein induces transcription of the novel fgl2 prothrombinase gene and elevated procoagulant activity in those strains that produce fulminant hepatitis. chinese hamster ovary cells cotransfected with a construct expressing nucleocapsid protein from susceptible strains and with a luciferase reporter construct containing the fgl2 promoter showed a 6-fold increase in luciferase activity com ...199910187767
dual interference with novel genes mfgl2 and mtnfr1 ameliorates murine hepatitis virus type 3-induced fulminant hepatitis in balb/cj mice.our studies and those of many others have implicated hepatocyte necrosis and apoptosis mediated by fibrinogen-like protein-2 (fgl2) prothrombinase and tumor necrosis factor receptor (tnfr) in the development of fulminant viral hepatitis, a disease with a mortality rate greater than 80% in cases lacking immediate organ transplantation. this study was designed to explore the efficacy of dual short hairpin rna (shrna) interference with fgl2 and tnfr1 in the treatment of murine hepatitis virus strai ...201020218879
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