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physico-chemical properties of mouse hepatitis virus (mhv-2) grown on dbt cell culture.some properties of a strain of mouse hepatitis virus, mhv-2, grown on dbt cells were determined using a plaque assay on the cells. viral growth was not inhibited by the presence of actinomycin d or 5-iodo-2-deoxyuridine. mhv-2 was completely inactivated by ether, chloroform, sodium deoxycholate or beta-propiolactone, but showed a moderate resistance to trypsin. heating at 56 c for 30 min did not completely abolish the virus infectivity. the virus was stable after heating at 50 c for 15 min in 1m ...197830881
adoptively transferred acute and chronic relapsing autoimmune encephalomyelitis in the pl/j mouse and observations on altered pathology by intercurrent virus infection.pl/j mice developed chronic relapsing experimental allergic encephalomyelitis (eae) after receiving syngeneic guinea pig basic protein (gpbp)-immune lymph node cells or spleen cells which were cultured in the presence of gpbp or the encephalitogenic n-terminal peptide of gpbp. the presence of l3t4+ cells and in vitro proliferation in response to gpbp are required for the successful transfer. pathologically, passively transferred eae in the virus-free pl/j strain was characterized by an infiltrat ...19872824923
the hemagglutinin-esterase of mouse hepatitis virus strain s is a sialate-4-o-acetylesterase.by comparative analysis of the hemagglutinin-esterase (he) protein of mouse hepatitis virus strain s (mhv-s) and the he protein of influenza c virus, we found major differences in substrate specificities. in striking contrast to the influenza c virus enzyme, the mhv-s esterase was unable to release acetate from bovine submandibulary gland mucin. furthermore, mhv-s could not remove influenza c virus receptors from erythrocytes. analysis with free sialic acid derivatives revealed that the mhv-s he ...199910233932
prevalence of naturally occurring viral infections, mycoplasma pulmonis and clostridium piliforme in laboratory rodents in western europe screened from 2000 to 2003.in this report prevalence rates of rodent viruses in laboratory animals are presented based on routine serological screening of mouse and rat colonies from european institutes. the prevalences found during the period 2000-2003 are compared with those reported for 1981-1984 and 1990-1993. it is shown that some infections were eliminated from laboratory animal colonies (e.g. k-virus and polyomavirus) by taking preventative measures whereas other infections such as mouse hepatitis virus and parvovi ...200616600073
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