| the dynamics of murid gammaherpesvirus 4 within wild, sympatric populations of bank voles and wood mice. | murid gammaherpesvirus 4 (muhv-4) is widely used as a small animal model for understanding gammaherpesvirus infections in man. however, there have been no epidemiological studies of the virus in wild populations of small mammals. as muhv-4 both infects cells associated with the respiratory and immune systems and attempts to evade immune control via various molecular mechanisms, infection may reduce immunocompetence with potentially serious fitness consequences for individuals. here we report a l ... | 2007 | 17347391 |
| host and viral traits predict zoonotic spillover from mammals. | the majority of human emerging infectious diseases are zoonotic, with viruses that originate in wild mammals of particular concern (for example, hiv, ebola and sars). understanding patterns of viral diversity in wildlife and determinants of successful cross-species transmission, or spillover, are therefore key goals for pandemic surveillance programs. however, few analytical tools exist to identify which host species are likely to harbour the next human virus, or which viruses can cross species ... | 2017 | 28636590 |
| the wood mouse is a natural host for murid herpesvirus 4. | infection of laboratory mice by the murid herpesvirus 4 (mhv-4) is a much studied model system for gammaherpesvirus pathogenesis. little, however, is known about its natural host range, epidemiology and pathogenesis outside the laboratory. we have studied mhv-4 infection in free-living murids in the uk. using a combination of serology and pcr analysis, we found that mhv-4 was endemic in wood mice (apodemus sylvaticus) but not in two species of voles (clethrionomys glareolus, microtus agrestis). ... | 2003 | 12533706 |
| epidemiology and fitness effects of wood mouse herpesvirus in a natural host population. | rodent gammaherpesviruses have become important models for understanding human herpesvirus diseases. in particular, interactions between murid herpesvirus 4 and mus musculus (a non-natural host species) have been extensively studied under controlled laboratory conditions. however, several fundamental aspects of murine gammaherpesvirus biology are not well understood, including how these viruses are transmitted from host to host, and their impacts on host fitness under natural conditions. here, w ... | 2012 | 22915692 |
| characterization of a novel wood mouse virus related to murid herpesvirus 4. | two novel gammaherpesviruses were isolated, one from a field vole (microtus agrestis) and the other from wood mice (apodemus sylvaticus). the genome of the latter, designated wood mouse herpesvirus (wmhv), was completely sequenced. wmhv had the same genome structure and predicted gene content as murid herpesvirus 4 (muhv4; murine gammaherpesvirus 68). overall nucleotide sequence identity between wmhv and muhv4 was 85 % and most of the 10 kb region at the left end of the unique region was particu ... | 2010 | 19940063 |
| pathogenesis of a model gammaherpesvirus in a natural host. | murine gammaherpesvirus 68 (mhv-68) infection of laboratory mice (mus musculus) is an established model of gammaherpesvirus pathogenesis. the fact that m. musculus is not a host in the wild prompted us to reassess mhv-68 infection in wood mice (apodemus sylvaticus), a natural host. here, we report significant differences in mhv-68 infection in the two species: (i) following intranasal inoculation, mhv-68 replicated in the lungs of wood mice to levels approximately 3 log units lower than in balb/ ... | 2010 | 20130062 |