two novel spliced genes in human cytomegalovirus.two novel spliced genes (ul131a and ul128) flanking ul130 were predicted from sequence comparisons between human cytomegalovirus (hcmv) and its closest known relative, chimpanzee cytomegalovirus (ccmv), and the splicing patterns were confirmed by mrna mapping experiments. both genes were transcribed with late kinetics and shared a polyadenylation site. comparisons with wild-type hcmv in infected human tissues showed that three of five isolates passaged in cell culture contained disruptions of ul ...200312692276
simian cytomegalovirus encodes five rapidly evolving chemokine receptor homologues.many herpesviruses, poxviruses and retroviruses encode proteins related to chemokines and chemokine receptors. the first one discovered, us28 of human cytomegalovirus (hcmv), is a 7-transmembrane domain g protein-coupled chemokine receptor able to activate diverse cellular responses, including cell migration and gene expression. a related orf named us27 is adjacent to us28, but no functions have been defined yet. recently orfs 3-7, a cluster of five concatenated orfs with highest homology to us2 ...200414739653
properties of virion transactivator proteins encoded by primate cytomegaloviruses.human cytomegalovirus (hcmv) is a betaherpesvirus that causes severe disease in situations where the immune system is immature or compromised. hcmv immediate early (ie) gene expression is stimulated by the virion phosphoprotein pp71, encoded by open reading frame (orf) ul82, and this transactivation activity is important for the efficient initiation of viral replication. it is currently recognized that pp71 acts to overcome cellular intrinsic defences that otherwise block viral ie gene expressio ...200919473490
antibodies in urine of chimpanzees with chronic adenoviral viruria.many chimpanzees have naturally occurring chronic intermittent viruria with an adenovirus of a new type called pan 11. small amounts of neutralizing antibodies to pan 11 adenovirus were found in the urine of chimpanzees. urinary antibodies to adenovirus were mainly of the immunoglobulin g (igg) class with some iga antibodies also present. there was no neutralizing activity in urine against another adenovirus, pan 9, which has been isolated from lymph nodes, but not from urine, of chimpanzees; ho ...1978211084
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