Publications

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kaposi's sarcoma: breeding ground of herpesviridae - a tour de force over viral evolution (review).after reviewing the molecular biological basis of prominent theories for the integration of viruses into the earliest forms of living matter, an account is given on the immunoevasive strategies viruses have had to acquire in order to secure their existence against the most sophisticated anti-viral defensive mechanisms evolving in their hosts. herpes-viridae and kaposi's sarcoma illustrate the complexity of host-virus relationship. in following the evolutionary steps of simians and hominoids to h ...199910087309
novel simian homologues of epstein-barr virus.thirty different lymphocryptoviruses (lcv), 26 of them novel, were detected in primates by a panherpesvirus pcr assay. nineteen lcv from chimpanzees, bonobos, gorillas, and other old world primates were closely related to epstein-barr virus (ebv), the type species of the genus lymphocryptovirus. seven lcv originating from new world primates were related to callitrichine herpesvirus 3 (calhv-3), the first recognized new world lcv. importantly, a second lcv from gorillas and three lcv from orangut ...200312970457
complete cdna sequences of the drb6 gene from humans and chimpanzees: a possible model of a stop codon readingthrough mechanism in primates.the defective major histocompatibility complex (mhc) drb6 gene is transcribed into mrna in human [peripheral blood lymphocytes, transfected and epstein-barr virus (ebv)] and chimpanzee ebv cell lines. mhc-drb6 presents several anomalies, which include stop codons in exon 2, lack of the usual polyadenilation signal of other mhc-drb genes, and a promoter region and exon 1 taken from a locally inserted retrovirus. the complete cdna sequences from human drb6*0201 and three common chimpanzee alleles ...199910436177
the first endogenous herpesvirus, identified in the tarsier genome, and novel sequences from primate rhadinoviruses and lymphocryptoviruses.herpesviridae is a diverse family of large and complex pathogens whose genomes are extremely difficult to sequence. this is particularly true for clinical samples, and if the virus, host, or both genomes are being sequenced for the first time. although herpesviruses are known to occasionally integrate in host genomes, and can also be inherited in a mendelian fashion, they are notably absent from the genomic fossil record comprised of endogenous viral elements (eves). here, we combine paleovirolo ...201424945689
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