subunit vaccine protects macaca nemestrina (pig-tailed macaque) against simian t-cell lymphotropic virus type i challenge.five macaques received two vaccinations consisting of soluble human t-cell lymphotropic virus type i proteins from a cell/serum-free human t-cell lymphotropic virus type i-producing cell line. five other macaques were vaccine controls. all were challenged with a simian t-cell lymphotropic virus type i-producing cell line. the vaccinated macaques generated a strong serological response to challenge as opposed to the control macaques. western blot analysis of the sera showed that both groups recog ...19902167165
evaluation of a htlv-1 subunit vaccine in prevention of experimental stlv-i infection in macaca nemestrina.pig-tailed macaques were vaccinated with a human t-cell lymphotropic virus type i (htlv-i) subunit vaccine. vaccinates and controls were challenged with simian t-cell lymphotropic virus type i (stlv-i)-infected cells. vaccination yielded antibody responses to htlv-i and stlv-i gag and env precursors. controls developed htlv-i and stlv-i antibody to gag and tax protein. immunization produced syncytium inhibiting antibody and cellular cytotoxicity to virus-infected cells. reverse transcriptase act ...19902172541
isolation of sooty mangabey simian t-cell leukemia virus type i [stlv-i(sm)] and characterization of a mangabey t-cell line coinfected with stlv-i(sm) and simian immunodeficiency virus has been postulated that dual infections of humans with human immunodeficiency virus (hiv) and human t-cell leukemia/lymphotropic virus (htlv) may potentiate disease progression. counterparts of both of these pathogenic human retroviruses have been identified in various simian species indigenous to asia and africa, including sooty mangabey monkeys (cercocebus atys). using peripheral blood mononuclear cells (pbmc) from a mangabey naturally infected with both siv and stlv-i, t-cell lines were e ...19979281507
isolation and characterization of a neuropathogenic simian immunodeficiency virus derived from a sooty mangabey.transfusion of blood from a simian immunodeficiency virus (siv)- and simian t-cell lymphotropic virus-infected sooty mangabey (designated fgb) to rhesus and pig-tailed macaques resulted in the development of neurologic disease in addition to aids. to investigate the role of siv in neurologic disease, virus was isolated from a lymph node of a pig-tailed macaque (designated pgm) and the cerebrospinal fluid of a rhesus macaque (designated ron2) and passaged to additional macaques. siv-related neuro ...19989765429
association of primate t-cell lymphotropic virus infection of pig-tailed macaques with high mortality.natural infection of humans with human t-cell lymphotropic virus type i (htlv-i) and of old world nonhuman primates with the simian counterpart, stlv-i, is associated with development of neoplastic disease in a small percentage of individuals after long latent periods. htlv-i is also the etiologic agent of a more rapidly progressive neurologic disease, htlv-i-associated myelopathy/tropical spastic paraparesis (ham/tsp). macaques have been used experimentally in studies to evaluate htlv-i candida ...200212504576
a novel epstein-barr virus-like virus, hv(mne), in a macaca nemestrina with mycosis fungoides.epstein-barr virus (ebv) infection of humans has been associated with the development of lymphoid malignancies mainly of b-cell lineage, although occasionally t-cell lymphomas have been reported. we describe here the characterization of a novel ebv-like virus (hv(mne)) isolated from a simian t-cell lymphotropic virus type i/ii (stlv-i/ii) seronegative pigtailed macaque (macaca nemestrina) with a cutaneous t-cell lymphoma. immunohistochemistry studies on the skin lesions demonstrated that the inf ...199910477739
simian t-lymphotropic virus type i infection among wild-caught indonesian pig-tailed macaques (macaca nemestrina).evidence for the presence of simian t-lymphotropic viruses (stlv-i) was identified in live-caught pig-tailed macaques from two locations in southern sumatra, indonesia. of 60 animals tested, 13.3% of the animals showed seroreactivity to htlv-i/ii enzyme-linked immunosorbent assay (elisa) antigens. of these, 75% showed indeterminate reactivity and 25% showed positive reactivity to htlv-i/ii western blot antigens. polymerase chain reaction (pcr) analysis of 6 of 8 seroreactive monkeys' peripheral ...19989859970
efficacy of an htlv-1 subunit vaccine in prevention of a stlv-1 infection in pig-tailed macaques.three pig-tailed macaques were vaccinated twice, four weeks apart, with a human t-cell lymphotropic virus type 1 (htlv-1) subunit vaccine. four weeks post-vaccination, the vaccinated macaques and two control monkeys were challenged with a simian t-cell lymphotropic virus type 1 (stlv-1)-infected cell line. following the first vaccination, an antibody response developed to htlv-1 and stlv-1 viral proteins as visualized by western blot. the antibody recognized both gag and env protein precursors a ...19902178125
coinfection of macaques with simian immunodeficiency virus and simian t cell leukemia virus type i: effects on virus burdens and disease test the hypothesis that coinfection with human immunodeficiency virus (hiv) and human t cell leukemia/lymphoma virus types i or ii (htlv-i or -ii) accelerates progression to aids, pig-tailed macaques were inoculated with the simian counterparts, siv and stlv-i. during 2 years of follow-up of singly and dually infected macaques, no differences in siv burdens, onset of disease, or survival were detected. however, in the first coinfected macaque that died of aids (1 year after infection), >50% ...19999952366
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