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vaccination with cancer- and hiv infection-associated endogenous retrotransposable elements is safe and immunogenic.the expression of endogenous retrotransposable elements, including long interspersed nuclear element 1 (line-1 or l1) and human endogenous retrovirus, accompanies neoplastic transformation and infection with viruses such as hiv. the ability to engender immunity safely against such self-antigens would facilitate the development of novel vaccines and immunotherapies. in this article, we address the safety and immunogenicity of vaccination with these elements. we used immunohistochemical analysis a ...201222745376
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