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establishment of primate lymphoblastic cell lines by coculture with a simian t-cell leukemia virus-1 positive, hypoxanthine-guanine-phosphoribosyltransferase negative japanese macaque cell line.a cell line (jamh17+) resistant to 8-azaguanine was established from a human t-cell leukemia virus type 1 related virus (simian t-cell leukemia virus-1) positive japanese macaque cell line. lymphoblastic cell lines were established from the peripheral blood mononuclear cells of humans, hominoids, and several species of macaques by coculture with jamh17+ in hypoxanthine-aminopterin-thymidine medium. htlv-1 specific antigen was detected in some of the established cell lines. phenotypic analysis sh ...19882835483
immune recognition of genetically diverse simian t-cell lymphotropic virus type i isolates.nucleotide sequence analysis of selected regions of the gag, pol, env and px genes of simian t-cell lymphotropic virus type i (stlv-i) strains indicated that african isolates were more closely related to human t-cell lymphotropic virus type i (htlv-i) than asian isolates. despite these recent comparative studies on nucleotide sequence homology between htlv-i and stlv-i isolates, only limited information is available regarding the influence of genetic differences on antigen-antibody recognition o ...19957535998
genetic analysis and molecular phylogeny of simian t-cell lymphotropic virus type i: evidence for independent virus evolution in asia and africa.type c retroviruses, designated simian t-cell lymphotropic virus type i (stlv-i), have been isolated from several genera of old world monkeys and apes, but not from new world monkeys and prosimians. to determine the genomic diversity and molecular evolution of stlv-i and to clarify their genetic relationship to human t-cell lymphotropic virus type i (htlv-i), we enzymatically amplified, then directly sequenced selected regions of the gag, pol, env, and px genes of stlv-i strains from asia and af ...19948116255
malignant nk/t-cell lymphoma associated with simian epstein-barr virus infection in a japanese macaque (macaca fuscata).a case of spontaneous malignant lymphoma in a japanese macaque (macaca fuscata) was pathologically, etiologically and virologically studied. nasal cavity was involved in the neoplastic lesions in addition to lymphoid and visceral tissues. histopathological analyses revealed the presence of neoplastic cells classified into histiocytic hodgkin-like cells and reed-sternberg-like cells. histiocytic hodgkin-like cells were cd16+ and cd20+, and the cd16+ cells were also positive for simian epstein-bar ...200515725687
enhancement of anti-stlv-1/htlv-1 immune responses through multimodal effects of anti-ccr4 antibody.human t-cell leukemia virus type 1 (htlv-1) causes adult t-cell leukemia and inflammatory diseases. because anti-htlv-1 immune responses are critical for suppressing infected cells, enhancing cellular immunity is beneficial for the treatment of htlv-1-associated diseases. using simian t-cell leukemia virus type 1 (stlv-1) infected japanese macaques, we analyzed the immune responses to viral antigens and the dynamics of virus-infected cells. the chemokine receptor ccr4 is expressed on stlv-1 infe ...201627250643
characterization of simian t-cell leukemia virus type 1 in naturally infected japanese macaques as a model of htlv-1 infection.human t-cell leukemia virus type 1 (htlv-1) causes chronic infection leading to development of adult t-cell leukemia (atl) and inflammatory diseases. non-human primates infected with simian t-cell leukemia virus type 1 (stlv-1) are considered to constitute a suitable animal model for htlv-1 research. however, the function of the regulatory and accessory genes of stlv-1 has not been analyzed in detail. in this study, stlv-1 in naturally infected japanese macaques was analyzed.201324156738
short communication: epidemiological evidence that simian t-lymphotropic virus type 1 in macaca fuscata has an alternative transmission route to maternal infection.serological inspection of simian t-lymphotropic virus type 1 was conducted for a wild colony of macaca fuscata, which was captured in the middle honshu, japan. the increase of positive rate after the juvenile stage with the positive rate reaching 100% (or 35/35) in youngster and adult stages, was observed. this finding suggests that, in contrast with human t-lymphotropic virus type 1, horizontal transmission play an important role in increasing prevalence of stlv-1 with age among m. fuscata.201120854200
tcf1 and lef1 act as t-cell intrinsic htlv-1 antagonists by targeting tax.human t-cell leukemia virus type 1 (htlv-1) is a delta-type retrovirus that induces malignant and inflammatory diseases during its long persistence in vivo. htlv-1 can infect various kinds of cells; however, htlv-1 provirus is predominantly found in peripheral cd4 t cells in vivo. here we find that tcf1 and lef1, two wnt transcription factors that are specifically expressed in t cells, inhibit viral replication through antagonizing tax functions. tcf1 and lef1 can each interact with tax and inhi ...201525646419
detection of simian t-lymphotropic virus type i using the polymerase chain reaction.to develop the polymerase chain reaction (pcr) for the detection of simian t-lymphotropic virus type i (stlv-i) infection, cell lines or peripheral-blood mononuclear cells (pbmc) from 2 non-human primate species [african green monkeys (agm), cercopithecus aethiops; baboon, papio cynocephalus] were evaluated for their stlv-i status using oligonucleotide primer pairs and probes specific for the tax and pol gene regions of the closely related human t-lymphotropic virus type i (htlv-i). these pcr re ...19921312066
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