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induction of fc (igg) receptor(s) by simian cytomegaloviruses in human embryonic lung fibroblasts.human embryonic lung (hel) fibroblasts infected with simian cytomegalovirus (scmv) were found to bind nonspecifically to the fc portion of human immunoglobulin (ig) g (igg). binding of igg to scmv-infected hel fibroblasts, but not to uninfected hel cells, was visualized as cytoplasmic fluorescence by the indirect immunofluorescence test, regardless of the presence of anti-cmv antibodies. the receptor(s) reacted with the igg class of different species, but not with igm and iga. the purified fc fr ...19882852656
simian cytomegalovirus-related stealth virus isolated from the cerebrospinal fluid of a patient with bipolar psychosis and acute encephalopathy.a cytopathic 'stealth' virus was cultured from the cerebrospinal fluid of a patient with a bipolar psychotic disorder who developed a severe encephalopathy leading to a vegetative state. dna sequencing of a polymerase chain reaction-amplified product from infected cultures has identified the virus as an african green monkey simian cytomegalovirus (scmv)-related stealth virus. the virus is similar to the scmv-related stealth virus isolated from a patient with chronic fatigue syndrome. the finding ...19968888270
detection of rna sequences in cultures of a stealth virus isolated from the cerebrospinal fluid of a health care worker with chronic fatigue syndrome. case report.a cytopathic stealth virus was cultured from the cerebrospinal fluid of a nurse with chronic fatigue syndrome. reverse transcriptase-polymerase chain reaction (rt-pcr) performed on the patient's culture yielded positive results with primer sets based on sequences of a previously isolated african green monkey simian-cytomegalovirus-derived stealth virus. the same primer sets did not yield pcr products when tested directly on dna extracted from the cultures. the findings lend support to the possib ...19979200191
cellular sequences in stealth viruses.cloned dna obtained from the culture of an african green monkey simian cytomegalovirus-derived stealth virus contains multiple discrete regions of significant sequence homology (p values ranging from 4 x 10(-3) to 1 x 10(-20)) to portions of known human cellular genes. the stealth virus was cultured from a patient with chronic fatigue syndrome (cfs). earlier studies had revealed considerable sequence heterogeneity within dna fragments isolated from virus-infected cells. a set of polymerase chain ...19989645627
stealth adaptation of an african green monkey simian cytomegalovirus.dna extracted from cultures of a cytopathic virus isolated from a patient with chronic fatigue syndrome was cloned into pbluescript plasmid. the nucleotide sequences of the plasmid inserts were analyzed using the blastn and blastx programs of the national center for biotechnology information. in confirmation of earlier studies, many of the sequences show partial homology to various regions within the genome of human cytomegalovirus (hcmv). the matching regions were unevenly distributed throughou ...199910331958
bacteria-related sequences in a simian cytomegalovirus-derived stealth virus culture.extensive sequencing of cloned dna isolated from the culture of an african green monkey simian cytomegalovirus-derived stealth virus has identified multiple regions of highly significant homology to various bacterial genes. the apparent acquisition of bacterial sequences extends the potential role of stealth viruses as natural vectors in the transfer of genetic information. the findings highlight the dynamic interface between viral and bacterial genomes and the potential of this interaction in t ...199910331959
melanoma growth stimulatory activity (mgsa/gro-alpha) chemokine genes incorporated into an african green monkey simian cytomegalovirus-derived stealth virus.dna isolated from the culture of an african green monkey simian cytomegalovirus (scmv)-derived stealth virus has been cloned. a region of the virus that contains genes coding proteins homologous to the ul141, ul144, and ul145 proteins of human cytomegalovirus has recombined with cellular sequences encoding several distinct copies of the melanoma growth stimulatory activity (mgsa/gro-alpha) chemokine gene. this finding illustrates the capacity of stealth viruses to capture, amplify, and mutate ge ...199910331960
chemokine receptor-related genetic sequences in an african green monkey simian cytomegalovirus-derived stealth virus.the us28 gene of human cytomegalovirus (hcmv) codes a cell surface receptor for both beta chemokine and fractalkine molecules. this receptor facilitates hcmv-induced cell fusion and virus dissemination and influences susceptibility to infection with other viruses, including the human immunodeficiency virus. five adjacent but divergent open reading frames that potentially code for molecules related to the us28 protein of hcmv are present in an african green monkey simian cytomegalovirus-derived s ...200010891288
simian cytomegalovirus and contamination of oral poliovirus vaccines.in the 1950s the use of primary rhesus macaque kidney cultures to propagate poliovirus for vaccine production led to the contamination of vaccines with simian virus 40 (sv40). african green monkey kidney (agmk) cultures free of sv40 were used as an alternative cell substrate for vaccine manufacture. in this study we evaluate oral poliovirus seeds, vaccine bulks and vaccines themselves for the presence of a common contaminant of agmk cultures, simian cytomegalovirus (scmv). using sensitive polyme ...200312623061
simian cytomegalovirus encodes five rapidly evolving chemokine receptor homologues.many herpesviruses, poxviruses and retroviruses encode proteins related to chemokines and chemokine receptors. the first one discovered, us28 of human cytomegalovirus (hcmv), is a 7-transmembrane domain g protein-coupled chemokine receptor able to activate diverse cellular responses, including cell migration and gene expression. a related orf named us27 is adjacent to us28, but no functions have been defined yet. recently orfs 3-7, a cluster of five concatenated orfs with highest homology to us2 ...200414739653
african green monkey origin of the atypical cytopathic 'stealth virus' isolated from a patient with chronic fatigue syndrome.a cytomegalovirus-like 'stealth virus' had previously been isolated from a patient with the chronic fatigue syndrome (cfs).199515566831
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