| deregulation of cell growth by the k1 gene of kaposi's sarcoma-associated herpesvirus. | at a position equivalent to the gene encoding the saimiri transforming protein (stp) of herpesvirus saimiri (hvs), kaposi's sarcoma-associated herpesvirus (kshv) contains a distinct open reading frame called k1. although kshv and hvs are related members of the rhadinovirus subgroup of gamma herpesviruses, k1 and stp exhibit no similarity in amino acid sequence or in structural organization. since stp is required for the oncogenic potential of hvs, we investigated the functional consequence of k1 ... | 1998 | 9546789 |
| expression in a recombinant murid herpesvirus 4 reveals the in vivo transforming potential of the k1 open reading frame of kaposi's sarcoma-associated herpesvirus. | murid herpesvirus 4 (commonly called mhv-68) is closely related to kaposi's sarcoma-associated herpesvirus (kshv) and provides an excellent model system for investigating gammaherpesvirus-associated pathogenesis. mhv-76 is a naturally occurring deletion mutant of mhv-68 that lacks 9,538 bp of the left end of the unique portion of the genome encoding nonessential pathogenesis-related genes. the kshv k1 protein has been shown to transform rodent fibroblasts in vitro and common marmoset t lymphocyt ... | 2004 | 15280496 |
| non-human primate model of kaposi's sarcoma-associated herpesvirus infection. | since kaposi's sarcoma-associated herpesvirus (kshv or human herpesvirus 8) was first identified in kaposi's sarcoma (ks) lesions of hiv-infected individuals with aids, the basic biological understanding of kshv has progressed remarkably. however, the absence of a proper animal model for kshv continues to impede direct in vivo studies of viral replication, persistence, and pathogenesis. in response to this need for an animal model of kshv infection, we have explored whether common marmosets can ... | 2009 | 19798430 |
| complete genomic sequence of an epstein-barr virus-related herpesvirus naturally infecting a new world primate: a defining point in the evolution of oncogenic lymphocryptoviruses. | callitrichine herpesvirus 3 (calhv-3) was isolated from a b-cell lymphoma arising spontaneously in the new world primate callithrix jacchus, the common marmoset. partial genomic sequence analysis definitively identified calhv-3 as a member of the epstein-barr virus (ebv)-related lymphocryptovirus (lcv) genus and extended the known host range of lcvs beyond humans and old world nonhuman primates. we have now completed the first genomic sequence of an lcv infecting a new world primate by describin ... | 2002 | 12414947 |