| comparative live bioluminescence imaging of monkeypox virus dissemination in a wild-derived inbred mouse (mus musculus castaneus) and outbred african dormouse (graphiurus kelleni). | monkeypox virus belongs to the orthopoxvirus genus, infects rodents and monkeys in africa, produces a smallpox-like zoonotic disease in humans, and has the potential for global spread and exploitation for bioterrorism. several small animal models for studying monkeypox virus pathogenesis have been investigated. the african dormouse is a candidate natural host but is outbred and no immunological reagents exist. although not a natural host, the cast/eij mouse is inbred and animals and reagents are ... | 2015 | 25462355 |
| jumping and gliding rodents: mitogenomic affinities of pedetidae and anomaluridae deduced from an rna-seq approach. | an rna-seq strategy was used to obtain the complete set of protein-coding mitochondrial genes from two rodent taxa. thanks to the next generation sequencing (ngs) 454 approach, we determined the complete mitochondrial dna genome from graphiurus kelleni (mammalia: rodentia: gliridae) and partial mitogenome from pedetes capensis (pedetidae), and compared them with published rodent and outgroup mitogenomes. we finished the mitogenome sequencing by a series of amplicons using conserved pcr primers t ... | 2013 | 23973722 |
| management and care of african dormice (graphiurus kelleni). | african dormice (graphiurus spp.) are small nocturnal rodents that currently are uncommon in laboratory settings. their use may increase as they have recently been shown to develop an infection with monkeypox virus and may prove to be a valuable animal model for infectious disease research. because african dormice are not commercially available, an extensive breeding colony is required to produce the animals needed for research use. husbandry modifications that increased the production of offspr ... | 2010 | 20353691 |
| experimental infection of an african dormouse (graphiurus kelleni) with monkeypox virus. | suitable animal models are needed to study monkeypox virus (mpxv) as human monkeypox clinically resembles smallpox and mpxv is a zoonotic and potential bioterroristic agent. we have demonstrated that a species of african dormice, graphiurus kelleni, is susceptible to a lethal infection of mpxv and that mpxv replicated in multiple organs of this species. following intranasal administration, mpxv replicated locally in the nasal mucosa causing necrosis and hemorrhage with subsequent systemic spread ... | 2009 | 18977501 |
| evaluation of taterapox virus in small animals. | taterapox virus (tatv), which was isolated from an african gerbil (tatera kempi) in 1975, is the most closely related virus to variola; however, only the original report has examined its virology. we have evaluated the tropism of tatv in vivo in small animals. we found that tatv does not infect graphiurus kelleni, a species of african dormouse, but does induce seroconversion in the mongolian gerbil (meriones unguiculatus) and in mice; however, in wild-type mice and gerbils, the virus produces an ... | 2017 | 28763036 |