Publications

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establishment, immortalisation and characterisation of pteropid bat cell lines.bats are the suspected natural reservoir hosts for a number of new and emerging zoonotic viruses including nipah virus, hendra virus, severe acute respiratory syndrome coronavirus and ebola virus. since the discovery of sars-like coronaviruses in chinese horseshoe bats, attempts to isolate a sl-cov from bats have failed and attempts to isolate other bat-borne viruses in various mammalian cell lines have been similarly unsuccessful. new stable bat cell lines are needed to help with these investig ...200920011515
the immune gene repertoire of an important viral reservoir, the australian black flying fox.bats are the natural reservoir host for a range of emerging and re-emerging viruses, including sars-like coronaviruses, ebola viruses, henipaviruses and rabies viruses. however, the mechanisms responsible for the control of viral replication in bats are not understood and there is little information available on any aspect of antiviral immunity in bats. massively parallel sequencing of the bat transcriptome provides the opportunity for rapid gene discovery. although the genomes of one megabat an ...201222716473
characterisation of novel micrornas in the black flying fox (pteropus alecto) by deep sequencing.bats are a major source of new and emerging viral diseases. despite the fact that bats carry and shed highly pathogenic viruses including ebola, nipah and sars, they rarely display clinical symptoms of infection. host factors influencing viral replication are poorly understood in bats and are likely to include both pre- and post-transcriptional regulatory mechanisms. micrornas are a major mechanism of post-transcriptional gene regulation, however very little is known about them in bats.201425128405
duration of maternal antibodies against canine distemper virus and hendra virus in pteropid bats.old world frugivorous bats have been identified as natural hosts for emerging zoonotic viruses of significant public health concern, including henipaviruses (nipah and hendra virus), ebola virus, and marburg virus. epidemiological studies of these viruses in bats often utilize serology to describe viral dynamics, with particular attention paid to juveniles, whose birth increases the overall susceptibility of the population to a viral outbreak once maternal immunity wanes. however, little is unde ...201323826322
unlocking bat immunology: establishment of pteropus alecto bone marrow-derived dendritic cells and macrophages.bats carry and shed many emerging infectious disease agents including ebola virus and sars-like coronaviruses, yet they rarely display clinical symptoms of infection. bat epithelial or fibroblast cell lines were previously established to study the bat immune response against viral infection. however, the lack of professional immune cells such as dendritic cells (dc) and macrophages has greatly limited the significance of current investigations. using pteropus alecto (p. alecto) gm-csf plus il4, ...201627934903
analysis of cathepsin and furin proteolytic enzymes involved in viral fusion protein activation in cells of the bat reservoir host.bats of different species play a major role in the emergence and transmission of highly pathogenic viruses including ebola virus, sars-like coronavirus and the henipaviruses. these viruses require proteolytic activation of surface envelope glycoproteins needed for entry, and cellular cathepsins have been shown to be involved in proteolysis of glycoproteins from these distinct virus families. very little is currently known about the available proteases in bats. to determine whether the utilizatio ...201525706132
comparative analysis of bat genomes provides insight into the evolution of flight and immunity.bats are the only mammals capable of sustained flight and are notorious reservoir hosts for some of the world's most highly pathogenic viruses, including nipah, hendra, ebola, and severe acute respiratory syndrome (sars). to identify genetic changes associated with the development of bat-specific traits, we performed whole-genome sequencing and comparative analyses of two distantly related species, fruit bat pteropus alecto and insectivorous bat myotis davidii. we discovered an unexpected concen ...201323258410
conditions affecting the timing and magnitude of hendra virus shedding across pteropodid bat populations in australia.understanding infection dynamics in animal hosts is fundamental to managing spillover and emergence of zoonotic infections. hendra virus is endemic in australian pteropodid bat populations and can be lethal to horses and humans. however, we know little about the factors driving hendra virus prevalence in resevoir bat populations, making spillover difficult to predict. we use hendra virus prevalence data collected from 13 000 pooled bat urine samples across space and time to determine if pulses o ...201728942750
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