Publications

induction of differentiation in human promyelocytic leukemia cell line hl60 by a new type of polyenes, falconensone a and its derivatives.	falconensones a and b are new type of yellow pigment isolated from the mycelial extract of ascomycetous fungi, emericella falconensis or emericella fruticulosa, whose structures are similar to retinoic acid (ra). to date, biological activities of falconensones have not been reported. herein, we reported that falconensone a inhibited growth of hl60 human leukemia cells, when used either singly or in combination with ra. falconensone a alone did not induce differentiation of hl60 cells. however, f ...	1998	9826436
induction of apoptosis in the human promyelocytic leukemia cell line hl60 by falconensone a and its derivatives, new polyenes.	falconensones a and b are a new type of yellow pigment with structural similarity to retinoic acid isolated from the mycelial extract of ascomycetous fungi, emericella falconensis or emericella fruticulosa. in the present study we show that falconensone a alone induced apoptosis of hl60 human leukemia cells, while falconensone b, the 4'-nor-methyl derivative of falconensone a, had much lower activity. the synthetic derivatives of falconensone a, falconensone a p-bromophenylhydrazone and falconen ...	2000	10864029