single- and multiple-clade influenza a h5n1 vaccines induce cross protection in ferrets.the rapid evolution, genetic diversity, broad host range, and increasing human infection with avian influenza a (h5n1) viruses highlight the need for an efficacious cross-clade vaccine. using the ferret model, we compared induction of cross-reactive immunity and protective efficacy of three single-clade h5n1 vaccines and a novel multiple-clade h5n1 vaccine, with and without mf59 adjuvant. reverse genetics (rg) was used to generate vaccine viruses containing the hemagglutinin (ha) and neuraminida ...200919406182
avian influenza viruses in wild land birds in northern vietnam.given a paucity of data on the occurrence of avian influenza viruses (aivs) in wild passerines and other small terrestrial species in southeast asia and the importance of highly pathogenic asian-strain h5n1 outbreaks in humans and domestic poultry in these areas, we focused on surveillance for influenza a viral nucleic acids and antibodies for aivs in wild-caught birds in northern vietnam. four of 197 serum samples collected in 2007 from black-crested bulbul (pycnonotus melanicterus), crow-bille ...201222247391
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