plasmodium relictum (lineage sgs1) and plasmodium ashfordi (lineage grw2): the effects of the co-infection on experimentally infected passerine birds.the effects of avian malaria parasites of the genus plasmodium on their hosts are insufficiently understood. this is particularly true for malarial co-infections, which predominant in many bird populations. we investigated effects of primary co-infection of plasmodium relictum (lineage sgs1) and plasmodium ashfordi (grw2) on experimentally infected naive juveniles of siskin spinus spinus, crossbill loxia curvirostra and starling sturnus vulgaris. all siskins and crossbills were susceptible but s ...201021050849
parallel telomere shortening in multiple body tissues owing to malaria infection.several studies have shown associations between shorter telomere length in blood and weakened immune function, susceptibility to infections, and increased risk of morbidity and mortality. recently, we have shown that malaria accelerates telomere attrition in blood cells and shortens lifespan in birds. however, the impact of infections on telomere attrition in different body tissues within an individual is unknown. here, we tested whether malarial infection leads to parallel telomere shortening i ...201627488651
the avian transcriptome response to malaria infection.malaria parasites are highly virulent pathogens which infect a wide range of vertebrates. despite their importance, the way different hosts control and suppress malaria infections remains poorly understood. with recent developments in next-generation sequencing techniques, however, it is now possible to quantify the response of the entire transcriptome to infections. we experimentally infected eurasian siskins (carduelis spinus) with avian malaria parasites (plasmodium ashfordi), and used high-t ...201525636457
the transcriptome of the avian malaria parasite plasmodium ashfordi displays host-specific gene expression.malaria parasites (plasmodium spp.) include some of the world's most widespread and virulent pathogens. our knowledge of the molecular mechanisms these parasites use to invade and exploit their hosts other than in mice and primates is, however, extremely limited. it is therefore imperative to characterize transcriptome-wide gene expression from nonmodel malaria parasites and how this varies across individual hosts. here, we used high-throughput illumina rna sequencing on blood from wild-caught e ...201728267239
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