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newcastle disease virus-based live attenuated vaccine completely protects chickens and mice from lethal challenge of homologous and heterologous h5n1 avian influenza viruses.h5n1 highly pathogenic avian influenza virus (hpaiv) has continued to spread and poses a significant threat to both animal and human health. current influenza vaccine strategies have limitations that prevent their effective use for widespread inoculation of animals in the field. vaccine strains of newcastle disease virus (ndv), however, have been used successfully to easily vaccinate large numbers of animals. in this study, we used reverse genetics to construct a ndv that expressed an h5 subtype ...200717050610
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