Publications

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frog virus 3-like infections in aquatic amphibian communities.frog virus 3 (fv3) and fv3-like viruses, are members of the genus ranavirus (family iridoviridae), and they have been associated with infectious diseases that may be contributing to amphibian population declines. we examined the mode of transmission of an fv3-like virus, and potential hosts and reservoirs of the virus in a local amphibian community. using the polymerase chain reaction to detect infected animals, we found an fv3-like virus in south-central ontario, canada, amphibian communities, ...200818263826
preliminary amphibian health survey in the delaware water gap national recreation area.to detect aquatic animal diseases of national concern, 111 individual amphibians, including wood frogs rana sylvatica (28), spring peepers pseudacris crucifer (35), red-spotted newts notophthalmus viridescens (41), and gray tree frogs hyla versicolor (7), were sampled at seven different sites in the delaware water gap national recreation area (dgnra), pennsylvania, from june 14 to july 19, 2007. these samples were screened for batrachochytrium dendrobatidis and viral pathogens at the u.s. fish a ...201020848885
the benefits of coinfection: trematodes alter disease outcomes associated with virus infection.1.coinfections are increasingly recognized as important drivers of disease dynamics. consequently, greater emphasis has been placed on integrating principles from community ecology with disease ecology to understand within-host interactions among parasites. using larval amphibians and two amphibian parasites (ranaviruses and the trematode echinoparyphium sp.), we examined the influence of coinfection on disease outcomes. 2.our first objective was to examine how priority effects (the timing and s ...201728317105
pathogenesis of frog virus 3 ( ranavirus, iridoviridae) infection in wood frogs ( rana sylvatica).wood frogs ( rana sylvatica) are highly susceptible to infection with frog virus 3 (fv3, ranavirus, iridoviridae), a cause of mass mortality in wild populations. to elucidate the pathogenesis of fv3 infection in wood frogs, 40 wild-caught adults were acclimated to captivity, inoculated orally with a fatal dose of 10(4.43) pfu/frog, and euthanized at 0.25, 0.5, 1, 2, 4, 9, and 14 days postinfection (dpi). mild lesions occurred sporadically in the skin (petechiae) and bone marrow (necrosis) during ...201728060677
reciprocal effects of pesticides and pathogens on amphibian hosts: the importance of exposure order and timing.ecological communities are increasingly exposed to natural and anthropogenic stressors. while the effects of individual stressors have been broadly investigated, there is growing evidence that multiple stressors are frequently encountered underscoring the need to examine interactive effects. pesticides and infectious diseases are two common stressors that regularly occur together in nature. given the documented lethal and sublethal effects of each stressor on individuals, there is the potential ...201727939635
hematologic reference intervals for rana sylvatica (lithobates sylvaticus) and effect of infection with frog virus 3 (ranavirus sp., iridoviridae).although the wood frog, rana sylvatica, is used in research on infectious diseases of amphibians, hematologic ris or response to infection have not been established.201627564850
water temperature affects susceptibility to ranavirus.the occurrence of emerging infectious diseases in wildlife populations is increasing, and changes in environmental conditions have been hypothesized as a potential driver. for example, warmer ambient temperatures might favor pathogens by providing more ideal conditions for propagation or by stressing hosts. our objective was to determine if water temperature played a role in the pathogenicity of an emerging pathogen (ranavirus) that infects ectothermic vertebrate species. we exposed larvae of fo ...201627283058
clinical signs, pathology and dose-dependent survival of adult wood frogs, rana sylvatica, inoculated orally with frog virus 3 ranavirus sp., iridoviridae.amphibian populations suffer massive mortalities from infection with frog virus 3 fv3, genus ranavirus, family iridoviridae, a pathogen also involved in mortalities of fish and reptiles. experimental oral infection with fv3 in captive-raised adult wood frogs, rana sylvatica lithobates sylvaticus, was performed as the first step in establishing a native north american animal model of ranaviral disease to study pathogenesis and host response. oral dosing was successful ld50 was 10(2.93 2.423.44) p ...201525593158
environmental dependency of amphibian-ranavirus genotypic interactions: evolutionary perspectives on infectious diseases.the context-dependent investigations of host-pathogen genotypic interactions, where environmental factors are explicitly incorporated, allow the assessment of both coevolutionary history and contemporary ecological influences. such a functional explanatory framework is particularly valuable for describing mortality trends and identifying drivers of disease risk more accurately. using two common north american frog species (lithobates pipiens and lithobates sylvaticus) and three strains of frog v ...201425469155
phylogenetic analysis of a frog virus 3-like ranavirus found at a site with recurrent mortality and morbidity events in southeastern ontario, canada: partial major capsid protein sequence alone is not sufficient for fine-scale differentiation.ranaviruses are emerging pathogens of amphibians. we examined the phylogenetic relationship of ranaviruses from infected lithobates sylvaticus tadpoles 2001-2004 from oliver pond, ontario, canada. the isolates sequenced are primarily frog virus 3-like, but because of sequence convergence, finer-scale analysis based on the major capsid protein was uninformative.201323568931
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