Publications

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establishment of three cell lines from chinese giant salamander and their sensitivities to the wild-type and recombinant ranavirus.known as lethal pathogens, ranaviruses have been identified in diseased fish, amphibians (including chinese giant salamander andrias davidianus, the world's largest amphibian) and reptiles, causing organ necrosis and systemic hemorrhage. here, three chinese giant salamander cell lines, thymus cell line (gstc), spleen cell line (gssc) and kidney cell line (gskc) were initially established. their sensitivities to ranaviruses, wild-type andrias davidianus ranavirus (adrv) and recombinant rana gryli ...201526070783
complete genome sequence of a ranavirus isolated from chinese giant salamander (andrias davidianus).a ranavirus (rv) was isolated from chinese giant salamanders (andrias davidianus) in china in 2010 and provisionally designated andrias davidianus ranavirus (adrv). the complete genome sequence is 106,719 nucleotides long. genomic sequence and phylogenetic analyses showed that adrv has a high degree of conservation with other rvs.201424407629
genomic sequencing of ranaviruses isolated from edible frogs (pelophylax esculentus).ranaviruses were isolated from wild edible frogs (pelophylax esculentus) during epizootics in denmark and italy. phylogenomic analyses revealed that these isolates are closely related and belong to a clade of ranaviruses that includes the andrias davidianus ranavirus (adrv), common midwife toad ranavirus (cmtv), testudo hermanni ranavirus (thrv), and pike-perch iridovirus (ppiv).201728935748
extensive diversification of mhc in chinese giant salamanders andrias davidianus (anda-mhc) reveals novel splice variants.a series of mhc alleles (including 26 class ia, 27 class iia, and 17 class iib) were identified from chinese giant salamander andrias davidianus (anda-mhc). these genes are similar to classical mhc molecules in terms of characteristic domains, functional residues, deduced tertiary structures and genetic diversity. the majority of variation between alleles is found in the putative peptide-binding region (pbr), which is driven by positive darwinian selection. the coexistence of two isoforms in mhc ...201424135718
genome architecture changes and major gene variations of andrias davidianus ranavirus (adrv).ranaviruses are emerging pathogens that have led to global impact and public concern. as a rarely endangered species and the largest amphibian in the world, the chinese giant salamander, andrias davidianus, has recently undergone outbreaks of epidemic diseases with high mortality. in this study, we isolated and identified a novel ranavirus from the chinese giant salamanders that exhibited systemic hemorrhage and swelling syndrome with high death rate in china during may 2011 to august 2012. the ...201324143877
morphological changes in amphibian and fish cell lines infected with andrias davidianus ranavirus.andrias davidianus ranavirus (adrv) is an emerging viral pathogen that causes severe disease in chinese giant salamanders, the largest extant amphibian in the world. a fish cell line, epithelioma papulosum cyprinid (epc), and a new amphibian cell line, chinese giant salamander spleen cell (gssc), were infected with adrv and observed by light and electron microscopy. the morphological changes in these two cell lines infected with adrv were compared. cytopathic effect (cpe) began with rounding of ...201525728809
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